Phofo ea Sinomenine Hydrochloride

Thibela ho ruruha: E fokotsa ho ruruha.
Analgesic: E fana ka phomolo bohlokong.
Ho thibela sesole sa 'mele: Ho thibela ts'ebetso ea sesole sa 'mele.
Anti-rheumatic: E phekola ramatiki.
Tšireletso ea methapo: E sireletsa lisele tsa methapo hore li se ke tsa senyeha.
Anti-fibrotic: E thibela kapa e fokotsa fibrosis ea lisele.

Romella imeile ho rona

Qaqiso ea Sehlahisoa

Li-tag tsa Sehlahisoa

Selelekela sa Sehlahisoa

Sinomenine Hydrochloride ke motsoako oa lik'hemik'hale o nkiloeng semeleng sa Sinomenium acutum, se fumanehang haholo Asia Bochabela. Ke alkaloid e 'nileng ea sebelisoa ka setso meriana ea Chaena ka lebaka la thepa ea eona ea ho thibela ho ruruha le ho kokobetsa bohloko. Sebopeho sa hydrochloride ke letsoai le ntlafatsang ho qhibiliha le botsitso ba motsoako, e leng se etsang hore o lokele haholoanyane tšebeliso ea meriana.
Sinomenine Hydrochloride e ithutiloe ka lebaka la litlamorao tsa eona tse ka bang teng tsa phekolo ho phekoleng maemo a kang ramatiki, ka lebaka la bokhoni ba eona ba ho fetola sesole sa 'mele le ho fokotsa ho ruruha. E sebetsa ka ho thibela tlhahiso ea li-cytokine tse bakang ho ruruha le bathusi ba bang ba amehang karabelong ea ho ruruha.
Ntle le litlamorao tsa eona tsa ho thibela ho ruruha le ho kokobetsa bohloko, Sinomenine Hydrochloride e boetse e bontšitse bokhoni ba ho sireletsa methapo ea kutlo, ho thibela fibrosis, le mesebetsing ea ho thibela hlahala lithutong tse fapaneng tsa pele ho tleliniki.

Tlhaloso

Lebitso la Semmuso: (9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one, monohydrochloride
Nomoro ea CAS: 6080-33-7
Mantsoe a tšoanang: Cucoline NSC 76021
Foromo ea limolek'hule： C19H23NO4 • HCl
Boima ba Foromo: 365.9
Bohloeki: ≥98% Sekoli se kristale
Ho qhibiliha (Ithute ka Phapang ho Qhibiliheng)
DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 5 mg/ml
PBS (pH 7.2): 5 mg/ml
Tšimoloho: Semela/Sinomenium acutum
Tlhahisoleseding ea Thomello le Polokelo:
Polokelo -20°C
Thomello: Mocheso oa Kamore
Botsitso: ≥ lilemo tse 4

Ntho	Tlhaloso	Sephetho
Teko (HPLC)	98.0%	98.12%
Ponahalo	Phofo e tšoeu	Litumellano
Boholo ba Likaroloana	98% ho isa ho 80mesh	Litumellano
Monko o mobe	Tšobotsi	Litumellano
Latsoa	Tšobotsi	Litumellano
Litšobotsi tsa 'Mele
Tahlehelo ha ho omisoa	≤0.5%	0.38%
Molora	≤0.5%	0.46%
Litšepe tse boima
Tšepe e boima (joalo ka Pb)	Maemo a USP (<10ppm)	<10ppm
Arsenic (As)	≤2ppm	0.78ppm
Lead (Pb)	≤2ppm	1.13ppm
Cadmium (Cd)	≤lpm	0.36ppm
Mercary(Hg)	≤0.1ppm	0.01ppm
Masalla a Chefo e bolaeang likokoanyana	Ha e fumanoe	Ha e fumanoe
Palo yohle ya Dipoleiti	NMT 10000cfu/g	680 cfu/g
Tomoso le Hlobo kaofela	NMT 100cfu/g	87 cfu/g
E.Coli	NMT 30cfu/g	10 cfu/g
Salmonella	Tse mpe	Tse mpe
Qetello	E Lumellana le Maemo a Khamphani

Likaroloana

Litlamorao tse kholo tsa Sinomenine Hydrochloride li kenyelletsa:
(1) Thibelo ea ho ruruha: E fokotsa ho ruruha.
(2) Setlhare se kokobetsang bohloko: Se fana ka phomolo bohlokong.
(3) E thibelang sesole sa 'mele: E thibela ts'ebetso ea sesole sa 'mele.
(4) E loantšang ramatiki: E phekola ramatiki.
(5) Tšireletso ea methapo: E sireletsa lisele tsa methapo hore li se ke tsa senyeha.
(6) Anti-fibrotic: E thibela kapa e fokotsa fibrosis ea lisele.

Kopo

Sinomenine Hydrochloride e sebelisoa haholo-holo libakeng tse latelang:
(1) Rheumatology: Kalafo ea ramatiki.
(2) Taolo ea Bohloko: Ho Fokotsa bohloko bo sa foleng.
(3) Thibelo ea ho ruruha: Phokotso ea ho ruruha.
(4) Ho fetola sesole sa mmele: Ho fetola sesole sa mmele.
(5) Tšireletso ea methapo ea kutlo: Tšebeliso e ka bang teng mekhoeng ea phekolo ea tšireletso ea methapo ea kutlo.

Lintlha tsa Tlhahiso

Ts'ebetso ea tlhahiso ea Sinomenine Hydrochloride Powder e ka akaretsoa ka tsela e latelang:

Tokisetso ea Litlama:Ho hlwekisa le ho omisa semela se tala.
Ho ntša:Ho sebedisa dihlahiswa tse kang ethanol ho ntsha sinomenine ho tswa semeleng.
Ho tsepamisa maikutlo:Ho fetola motsoako hore o be mouoane ho kopanya dikahare tsa sinomenine.
Alkalization:Ho fetola pH ho fetolela sinomenine hore e be letswai la yona.
Ho Ntša Metsi le Metsi:Ho hloekisa ka dihlahiswa tsa tlhaho tse kang anisole kapa 1-heptanol.
Ho hlatsoa:Ho hlatsoa ka metsi ho tlosa litšila le mesaletsa ea lintho tse qhibilihang.
Ho eketsa asiti:Ho fokotsa pH ho etsa hore sinomenine hydrochloride e be matla.
Ho etsa kristale:Ho etsa likristale tsa sinomenine hydrochloride.
Karohano:Ho sefa kapa ho ntsha dikristale ka sehatsetsing ho arola dikristale ho tswa ho tharollo.
Ho omisa:Ho tlosa mongobo o setseng ho tsoa likristale.
Ho sila:Ho sila likristale tse omisitsoeng hore e be phofo e ntle.
Ho sila:Ho netefatsa kabo e lekanang ea boholo ba likaroloana.
Taolo ea Boleng:Ho lekoa bakeng sa bohloeki, ho tsepamisa maikutlo le maemo a likokoana-hloko.
Sephutheloana:Sephutheloana se hloekileng le se sireletsehileng bakeng sa ho ajoa.

Sephutheloana le Tšebeletso

Polokelo: Boloka sebakeng se pholileng, se omileng le se hloekileng, Sireletsa mongobo le khanya e tobileng.
Sephutheloana se Seholo: 25kg/moropa.
Nako ea ho etella pele: Matsatsi a 7 kamora odara ea hau.
Bophelo ba Shelofo: Lilemo tse 2.
Tlhokomeliso: Litlhaloso tse ikhethileng le tsona li ka finyelloa.

Mekhoa ea Tefo le ea ho Romela

Hlahisa
Ka tlase ho 100kg, Matsatsi a 3-5
Tšebeletso ea ntlo le ntlo e bonolo ho e lata

Ka Leoatleng
Ho feta 300kg, Matsatsi a ka bang 30
Ho hlokahala morekisi oa tumello ea litsebi tsa koung ho tloha koung ho ea koung

Ka Moyeng
100kg-1000kg, Matsatsi a 5-7
Ho hlokahala morekisi oa litsebi oa tumello ea litšebeletso tsa boema-fofane ho tloha boema-fofaneng ho ea boema-fofaneng