Lycorine Hydrochloride
Lycorine hydrochloride ke phofo e tšoeu ho isa ho e tšoeu e tsoang ho alkaloid lycorine, e fumanoang limela tsa Lycoris radiata (L'Her.), 'me ke ea lelapa la Amaryllidaceae. Lycorine hydrochloride e na le litlamorao tse fapaneng tsa pharmacological, ho kenyelletsa anti-tumor, anti-cancer, anti-HCV, anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenesis le thepa ea anti-malaria. E qhibiliha ka metsing, DMSO, le ethanol. Sebopeho sa eona sa lik'hemik'hale se khetholloa ke moralo o rarahaneng oa steroidal o nang le tatso e bohloko e nang le lihlopha tse ngata tse sebetsang, ho kenyeletsa lihlopha tsa hydroxyl le amino, tse tlatsetsang mesebetsing ea eona ea tlhaho.
| Lebitso la sehlahisoa | Lycorine hydrochloride CAS: 2188-68-3 | ||
| Mohloli oa Semela | Lycoris | ||
| Boemo ba polokelo | Boloka ka tiiso mocheso oa kamore | Letsatsi la tlaleho | 2024.08.24 |
| Ntho | Standard | Sephetho |
| Bohloeki（HPLC） | Lycorine hydrochloride≥98% | 99.7% |
| Ponahalo | Phofo e tšoeu | E lumellana |
| Sebopeho sa mmeleics | ||
| Boholo ba likaroloana | NLT100% 80Mesh | E lumellana |
| Tahlehelo ka ho omisa | ≤1.0% | 1.8% |
| E boima tšepe | ||
| Kakaretso ea litšepe | ≤10.0ppm | E lumellana |
| Ketapele | ≤2.0ppm | E lumellana |
| Mercury | ≤1.0ppm | E lumellana |
| Cadmium | ≤0.5ppm | E lumellana |
| Likokoana-hloko | ||
| Palo eohle ea libaktheria | ≤1000cfu/g | E lumellana |
| Tomoso | ≤100cfu/g | E lumellana |
| Escherichia coli | Ha e kenyelelitsoe | Ha e fumanwe |
| Salmonella | Ha e kenyelelitsoe | Ha e fumanwe |
| Staphylococcus | Ha e kenyelelitsoe | Ha e fumanwe |
| Liqeto | Ea tšoanelehang | |
Likaroloana:
(1) Bohloeki bo Phahameng:Sehlahisoa sa rona se sebetsoa ka hloko ho netefatsa boemo bo phahameng ba bohloeki, e leng sa bohlokoa bakeng sa katleho ea sona le polokeho lits'ebetsong tse fapaneng.
(2) Thepa ea Anticancer:E bonts'itse litlamorao tse kholo tsa anticancer khahlano le mefuta e fapaneng ea mofets'e, ka bobeli in vitro le vivo, ka mekhoa e joalo ka ho ts'oaroa ha cell cycle, triggering apoptosis, le inhibiting angiogenesis.
(3) Ketso e Thabisitsoeng Haholo:Lycorine hydrochloride ho lumeloa hore e sebelisana le liphofu tse ngata tsa limolek'hule, e fana ka katleho e pharaletseng khahlanong le lisele tsa mofetše.
(4) Chefo e Tlase:E bonts'a chefo e tlase ho lisele tse tloaelehileng, e leng ntlha ea bohlokoa molemong oa tšebeliso ea eona e le moemeli oa phekolo.
(5) Boemo ba Pharmacokinetic:Sehlahisoa se ithutoe bakeng sa pharmacokinetics ea sona, se bonts'a ho monya ka potlako le ho tlosoa ka potlako ho plasma, e leng bohlokoa bakeng sa ho etsa dosing le moralo oa kalafo.
(6) Liphello tsa Synergistic:Lycorine hydrochloride e bontšitse liphello tse ntlafetseng ha e sebelisoa hammoho le lithethefatsi tse ling, tse ka bang molemo ho hlōla ho hanyetsa lithethefatsi le ho ntlafatsa liphello tsa phekolo.
(7) E tšehelitsoe ke Lipatlisiso:Sehlahisoa se tšehetsoa ke lipatlisiso tse pharaletseng, ho fana ka motheo o tiileng oa tšebeliso ea eona ho nts'etsopele ea meriana le lits'ebetsong tsa bongaka.
(8) Tiisetso ea Boleng:Mehato e matla ea taolo ea boleng e ntse e le teng ho pholletsa le ts'ebetso ea tlhahiso ho netefatsa ho tsitsisa le ho tšepahala ha sehlahisoa.
(9) Lisebelisoa tse fapaneng:E loketse ho sebelisoa lipatlisisong le nts'etsopele bakeng sa lits'ebetso tsa meriana, ho kenyeletsoa ho sibolloa ha lithethefatsi le nts'etsopele ea kalafo ea mofetše.
(10) Ho lumellana:E entsoe ho latela litekanyetso tsa GMP ho netefatsa polokeho le katleho ea sehlahisoa.
(1) Indasteri ea meriana:Lycorine hydrochloride e sebelisoa ho nts'etsopele ea meriana e thibelang likokoana-hloko le ea kankere.
(2) Indasteri ea Biotechnology:E sebelisoa ho etsa lipatlisiso le nts'etsopele ea li-agent tse ncha tsa phekolo le metsoako ea meriana.
(3) Patlisiso ea lihlahisoa tsa tlhaho:Lycorine hydrochloride e ithutoa bakeng sa melemo ea eona ea bophelo bo botle le thepa ea bongaka.
(4) Indasteri ea lik'hemik'hale:E ka 'na ea sebelisoa e le lik'hemik'hale tse lipakeng tsa motsoako oa metsoako e meng.
(5) Indasteri ea temo:Lycorine hydrochloride e 'nile ea batlisisoa ka bokhoni ba eona e le chefo ea tlhaho le taolo ea kholo ea limela.
Ts'ebetso ea ho ntšoa ha lycorine hydrochloride hangata e kenyelletsa mehato e latelang ea bohlokoa ho netefatsa bohloeki ba solvent le ho ntlafatsa sekhahla sa ho hlaphoheloa:
(1) Khetho ea thepa e tala le kalafo ea pele:Khetha lisebelisoa tse tala tsa semela sa Amaryllidaceae, joalo ka li-bulbs tsa Amaryllis, 'me u li hlatsoe, u li omise le ho li pshatla ho netefatsa bohloeki ba lisebelisoa tse tala le ho rala motheo bakeng sa ho ntšoa ho latelang.
(2)Phekolo ea li-enzyme tse kopaneng:Sebelisa li-enzyme tse rarahaneng (tse kang cellulase le pectinase) ho lokisa lisebelisoa tse tala tse pshatlehileng ho senya marako a lisele tsa semela le ho ntlafatsa ts'ebetso e latelang ea ho ntšoa.
(3)Hlakola hydrochloric acid leaching:Kopanya lisebelisuoa tse tala tse entsoeng esale pele le tharollo ea dilute hydrochloric acid ho ntša lycorine. Tšebeliso ea hydrochloric acid e thusa ho eketsa ho qhibiliha ha lycorine, ka hona ho ntlafatsa ts'ebetso ea ho ntša.
(4)Ho ntšoa ka thuso ea Ultrasonic:Tšebeliso ea theknoloji ea ultrasonic-assisted extraction e ka potlakisa ts'ebetso ea ho qhibiliha ha lycorine ka har'a solvent le ho ntlafatsa ts'ebetso ea ho ntša le ho hloeka.
(5)Ho tlosoa ha chloroform:Ho ntšoa ho etsoa ka li-solvents tse kang chloroform, 'me lycorine e fetisoa ho tloha karolong ea metsi ho ea karolong ea manyolo ho tsoela pele ho hloekisa motsoako o lebisitsoeng.
(6)Ho hlaphoheloa ha solvent:Ka mor'a ts'ebetso ea ho ntša, solvent e khutlisetsoa ka mouoane kapa ka distillation ho fokotsa tšebeliso ea solvent le ho ntlafatsa moruo.
(7)Ho hloekisa le ho omisa:Ka mehato e nepahetseng ea ho hloekisa le ho omisa, phofo e hloekileng ea lycorine hydrochloride e fumanoa.
Ho pholletsa le ts'ebetso eohle ea ho ntša, ho laola khetho ea solvent, maemo a ho ntša (joaloka pH boleng, mocheso le nako), le mehato e latelang ea ho hloekisa ke senotlolo sa ho netefatsa bohloeki ba solvent le ho ntlafatsa lebelo la ho hlaphoheloa. Tšebeliso ea lisebelisoa tsa morao-rao tsa ho ntša le ho hloekisa, tse kang li-extractors tsa ultrasonic le li-high-performance liquid chromatography (HPLC), li boetse li thusa ho ntlafatsa katleho ea ho ntša le boleng ba sehlahisoa.
Polokelo: Boloka sebakeng se phodileng, se omileng, se hlwekileng, Sireletsa mongobong le leseding le otlolohileng.
Pakete e ngata: 25kg / moropa.
Nako ea ho etella pele: Matsatsi a 7 ka mor'a taelo ea hau.
Shelf Life: lilemo tse 2.
Tlhokomeliso: Litlhaloso tse ikhethileng le tsona li ka finyelloa.
Express
Ka tlase ho 100kg, matsatsi a 3-5
Tšebeletso ea ntlo le ntlo e bonolo ho nka thepa
Ka Leoatle
Ho feta 300kg, Hoo e ka bang Matsatsi a 30
Kou ho isa litšebeletsong tsa boema-kepe hoa hlokahala
Ka Moea
100kg-1000kg, 5-7Matsatsi
Boema-fofane ho ea litšebeletsong tsa boema-fofane ho hlokahala morekisi oa tumello ea litsebi
Bioway Organic e fumane litifikeiti tsa USDA le EU organic, BRC, ISO, HALAL, KOSHER, le HACCP.
Lycorine ke alkaloid ea tlhaho e ka fumanoang limela tse 'maloa, haholo-holo ka har'a lelapa la Amaryllidaceae. Mona ke limela tse tsejoang li na le lycorine:
Lycoris radiata(eo hape e tsejoang e le red spider lily kapa manjushage) ke setlama sa setso sa Machaena se nang le lycorine.
Leucojum aestivum(lehloa la lehlabula), le boetse le tsejoa hore le na le lycorine.
Ungernia sewertzowiike semela se seng sa lelapa la Amaryllidaceae se tlalehiloeng se na le lycorine.
Lebasetere la Hippeastrum (lily ea Easter)le limela tse ling tse amanang le Amaryllidaceae ke mehloli e tsebahalang ea lycorine.
Limela tsena li ajoa haholo libakeng tsa tropike le tsa tropike lefatšeng ka bophara 'me li na le nalane e telele ea tšebeliso ea bongaka ba setso. Ho ba teng ha lycorine limeleng tsena e bile taba ea lipatlisiso ka lebaka la bokhoni ba eona ba pharmacological, ho kenyeletsoa le litlamorao tsa eona tsa bohlokoa tsa anticancer joalo ka ha ho bonts'itsoe lithutong tse fapaneng.
Lycorine ke alkaloid ea tlhaho e nang le litlamorao tse ngata tsa pharmacological, ho kenyelletsa le ts'ebeliso ea eona e ka bang teng kalafong ea mofets'e. Le hoja e bontšitse liphello tse tšepisang lithutong tse fapaneng, ho na le litla-morao tse tlalehiloeng le maikutlo a amanang le tšebeliso ea eona:
Chefo e tlase: Lycorine le letsoai la eona la hydrochloride hangata li bonts'a chefo e tlase, e leng tšobotsi e ntle bakeng sa lits'ebetso tsa bongaka. E bonts'itsoe hore e na le litlamorao tse fokolang liseleng tse tloaelehileng tsa motho le litoeba tse phetseng hantle, e fana ka maikutlo a boemo bo itseng ba khetho ea lisele tsa mofetše holim'a lisele tse tloaelehileng.
Liphello tsa Nakoana tsa Emetic: Ho nyekeloa ke pelo le ho hlatsa ka nakoana ho 'nile ha hlokomeloa ka mor'a ente e ka tlas'a letlalo kapa ka methapo ea lycorine hydrochloride, hangata e fokotseha nakong ea lihora tse 2,5 ntle le ho ama ts'ireletso ea lik'hemik'hale kapa hematological.
Ha ho na Khokahano ea Likoloi e Senyehileng: Liphuputso li bontšitse hore litekanyetso tsa serial tsa lycorine ha li ame tšebelisano ea likoloi ho litoeba, joalokaha li lekoa ke tlhahlobo ea rotarod, e bontšang hore ha e lebise liphellong tse mpe tsa tsamaiso ea methapo ea bohareng (CNS) e amanang le taolo ea motlakase.
Tšusumetso ho Ts'ebetso ea Locomotor e Ikemetseng: Ka tekanyo ea 30 mg / kg, lycorine e 'nile ea hlokomeloa hore e senya ts'ebetso ea litoeba tse sa tloaelehang ho litoeba, joalokaha ho bontšoa ke ho fokotseha ha boitšoaro ba ho hōlisa le ho eketseha ha ho se sisinyehe.
Kakaretso ea Boitšoaro le Bophelo bo Botle: Tekanyetso ea 10 mg / kg ea lycorine ha ea ka ea senya boitšoaro bo akaretsang le boiketlo ba litoeba, e fana ka maikutlo a hore sena e ka ba tekanyo e nepahetseng bakeng sa litlhahlobo tsa katleho ea phekolo ea nakong e tlang.
Ha ho Litlamorao Tse Hlollang Tse Bohlokoa Boima ba 'Mele kapa Boemo ba Bophelo bo Botle: Tsamaiso ea lycorine le lycorine hydrochloride ha ea ka ea baka litla-morao tse hlokomelehang boima ba' mele kapa boemo ba bophelo bo botle ka kakaretso mefuteng ea litoeba tse nang le hlahala.
Ke habohlokoa ho hlokomela hore le hoja lycorine e bontšitse bokhoni ba lipatlisiso tsa pele ho nako, litekanyetso tsa nako e telele tsa chefo li ntse li haella. Lipatlisiso tse ling lia hlokahala ho utloisisa ka botlalo boemo ba eona ba polokeho, haholo-holo bakeng sa tšebeliso ea nako e telele le maemong a bongaka. Litla-morao le polokeho ea lycorine li ka fapana ho latela litekanyetso, mokhoa oa tsamaiso, le litšobotsi tsa mokuli ka mong. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u nahana ka tšebeliso ea tlatsetso efe kapa efe e ncha kapa kalafo.
