Phepelo ea Feme e Hloekileng ea β-Nicotinamide adenine dinucleotide (NAD)
β-Nicotinamide adenine dinucleotide (NAD) ke coenzyme e fumanoang liseleng tsohle tse phelang, e bapala karolo ea bohlokoa lits'ebetsong tse fapaneng tsa metabolism. E bohlokoa bakeng sa tlhahiso ea matla, tokiso ea DNA le ho supa lisele. NAD e teng ka mefuta e 'meli: NAD+ le NADH, tse amehang liketsong tsa redox, tse fetisang lielektrone nakong ea litsela tsa metabolism. NAD e bohlokoa bakeng sa ho boloka ts'ebetso ea sele le bophelo bo botle ka kakaretso, 'me maemo a eona a ka ama lits'ebetso tse fapaneng tsa fisioloji. E sebelisoa haholo meriana, theknoloji ea baeloji le indasteri ea lijo, hammoho le tlhahisong ea li-supplement le lijo tse sebetsang tse shebaneng le metabolism ea matla le bophelo bo botle ba sele. Femeteng, NAD e ka hlahisoa ka ho belisa, ho sebelisoa likokoana-hloko ho fetola limolek'hule tsa pele ho NAD. Ts'ebetso ea tlhahiso e kenyelletsa taolo e hlokolosi ea maemo a ho belisa ho ntlafatsa phetoho ea li-precursor ho NAD.
| Ntho | Boleng |
| Nomoro ea CAS | 53-84-9 |
| Mabitso a Mang | beta-Nicotinamide adenine dinucleotide |
| MF | C21H27N7O14P2 |
| Nomoro ea EINECS | 200-184-4 |
| Sebaka sa Tšimoloho | Chaena |
| Mofuta | Li-Intermediate tsa Agrochemical, Li-Intermediate tsa Dyestuff, Li-Intermediate tsa Tatso le Monko, Li-Intermediate tsa Lintho tsa Syntheses |
| Bohloeki | 99% |
| Kopo | Lisebelisoa tsa ho kopanya |
| Ponahalo | Phofo e tšoeu |
| Lebitso | beta-Nicotinamide adenine dinucleotide |
| MW | 663.43 |
| MF | C21H27N7O14P2 |
| Foromo | E tiileng |
| Ponahalo | Phofo e tšoeu |
| MOQ | 1kg |
| Mehlala | E fumaneha |
| Bophelo ba Shelofo | lilemo tse 2 |
Bohloeki bo Phahameng:NAD ea rona e hlahisoa ka ho sebelisa mekhoa e tsoetseng pele ea tlhahiso ho netefatsa bohloeki bo phahameng, e fihlela litekanyetso tse thata tsa boleng tse hlokahalang bakeng sa ts'ebeliso ea meriana, theknoloji ea baeloji le lijo.
Boleng bo Tsitsitseng:Re boloka mehato e tiileng ea taolo ea boleng nakong eohle ea tlhahiso ho netefatsa hore lihlahisoa tsa rona tsa NAD li fihlela litlhaloso tse hlokahalang le maemo a ts'ebetso ka linako tsohle.
Likopo tse Feto-fetohang:NAD ea rona e ka sebelisoa lits'ebetsong tse fapaneng, ho kenyeletsoa meriana, li-supplement tsa lijo, lijo tse sebetsang, le lits'ebetso tsa biotechnology, ka lebaka la karolo ea eona ea bohlokoa metabolism ea sele le tlhahiso ea matla.
Ho Latela Melao:Lihlahisoa tsa rona tsa NAD li latela maemo a taolo a machaba, li netefatsa hore li latela melaoana le melaoana e amehang bakeng sa polokeho le boleng.
Phepelo e Tšepahalang:Re na le bokgoni ba tlhahiso le bokgoni ba ho tsamaisa thepa ho fana ka phepelo e tshepahalang le e tsitsitseng ya NAD ho fihlela ditlhoko tsa bareki ba rona.
Tšehetso ea tekheniki:Sehlopha sa rona sa litsebi se ka fana ka tšehetso ea tekheniki le tataiso mabapi le ho sebelisa NAD lits'ebetsong tse fapaneng, ho netefatsa hore bareki ba rona ba ka eketsa melemo ea lihlahisoa tsa rona.
Ka kakaretso, lihlahisoa tsa rona tsa NAD li khetholloa ka bohloeki ba tsona bo phahameng, boleng bo tsitsitseng, ho tenyetseha, ho latela melao, phepelo e tšepahalang, le tšehetso e felletseng ea tekheniki, e leng se etsang hore li be ntle bakeng sa lits'ebetso tse fapaneng tsa indasteri le tsa khoebo.
β-Nicotinamide adenine dinucleotide (NAD) e hloekileng e fana ka mesebetsi e 'maloa le melemo e ka bang teng ea bophelo bo botle, ho kenyeletsoa:
Tlhahiso ea Matla:
NAD e bapala karolo ea bohlokoa tlhahisong ea adenosine triphosphate (ATP), chelete ea mantlha ea matla a sele. Ka ho nka karolo liketsong tsa redox, NAD e nolofalletsa phetiso ea lielektrone ts'ebetsong ea phosphorylation ea oxidative, e leng ea bohlokoa bakeng sa ho hlahisa ATP mitochondria.
Metabolism ea Sele:
NAD e ameha litseleng tse fapaneng tsa metabolism, ho kenyeletsoa glycolysis, potoloho ea tricarboxylic acid (TCA), le oxidation ea mafura acid. Mekhoa ena ke ea bohlokoa bakeng sa ho roba le ho sebelisa limatlafatsi bakeng sa tlhahiso ea matla le ts'ebetso ea sele.
Tokiso ea DNA:
NAD ke substrate e kopanetsoeng bakeng sa lienzyme tse amehang lits'ebetsong tsa tokiso ea DNA, joalo ka poly(ADP-ribose) polymerases (PARPs) le sirtuins. Lienzyme tsena li bapala karolo ea bohlokoa ho bolokeng botsitso ba genomic le ho lokisa tšenyo ea DNA e bakoang ke likhatello tse fapaneng.
Matšoao a Sele:
NAD e sebetsa e le substrate bakeng sa sirtuins, sehlopha sa liprotheine tse amehang ho laoleng lits'ebetso tsa sele tse kang tlhahiso ea liphatsa tsa lefutso, apoptosis, le karabelo ea khatello ea maikutlo. Sirtuins li ameha bophelong bo bolelele 'me li' nile tsa amahanngoa le melemo e ka bang teng ea bophelo bo botle.
Melemo e ka bang teng ea bophelo bo botle:
Phuputso e fana ka maikutlo a hore ho eketsa kapa ho fetola maemo a NAD ho ka ba le melemo e ka bang teng bophelong bo botle, ho kenyeletsoa ho tšehetsa ts'ebetso ea mitochondrial, ho khothaletsa botsofali bo phetseng hantle, le maemo a ka bang le tšusumetso a amanang le ho se sebetse hantle ha metabolism le khatello ea maikutlo ea sele.
Pure β-Nicotinamide adenine dinucleotide (NAD) e na le mefuta e fapaneng ya ditshebediso ho pholletsa le diindasteri tse fapaneng ka lebaka la karolo ya yona ya bohlokwa metabolism ya sele le tlhahiso ya matla. Tse ding tsa ditshebediso tsa bohlokwa tsa pure NAD di kenyeletsa:
Indasteri ea Meriana:
NAD e sebelisoa e le karolo ea bohlokoa mefuteng ea meriana, haholo-holo meriana e shebaneng le mathata a metabolism, ho se sebetse hantle ha mitochondrial, le maemo a amanang le botsofali. E boetse e sebelisoa lipatlisisong le nts'etsopele bakeng sa mekhoa e ka bang teng ea phekolo.
Litlatsetso tsa Lijo:
NAD e kenyelelitsoe lijong tse tlatsetsang tse reretsoeng ho tšehetsa bophelo bo botle ba lisele, metabolism ea matla le boiketlo ka kakaretso. Litlatsetso tsena li rekisoa ka lebaka la bokhoni ba tsona ba ho khothaletsa botsofali bo phetseng hantle le ts'ebetso ea metabolism.
Lijo le Lino tse Sebetsang:
NAD e sebelisoa ho nts'etsapele lijo le lino tse sebetsang tse etselitsoeng ho tšehetsa tlhahiso ea matla, bophelo bo botle ba lisele le botsitso ba metabolism. Lihlahisoa tsena li ka shebana le bareki ba batlang litsela tsa tlhaho tsa ho ntlafatsa bophelo ba bona ka kakaretso le matla.
Theknoloji ea baeloji:
NAD e sebelisoa lits'ebetsong tse fapaneng tsa theknoloji ea baeloji, ho kenyeletsoa le setso sa sele, ho belisoa le boenjiniere ba li-enzyme. E sebetsa e le cofactor ea bohlokoa liketsong tse ngata tsa enzymatic le litseleng tsa metabolism, e leng se etsang hore e be ea bohlokoa ho bioprocessing le tlhahisong ea bio.
Patlisiso le Nts'etsopele:
NAD e sebelisoa e le sesebelisoa sa lipatlisiso lilaboratoring tsa thuto le tsa indasteri ho ithuta metabolism ea sele, tlhahiso ea matla, le melemo ea bophelo bo botle e amanang le phetoho ea NAD. Hape ke taba ea lipatlisiso tsa saense bakeng sa litlamorao tsa eona botsofaling, mafung a metabolism le maemong a ho senyeha ha methapo.
Litlolo:
NAD e kenyelelitsoe lihlahisoa tsa tlhokomelo ea letlalo le litlolo ka lebaka la bokhoni ba eona ba ho tšehetsa bophelo bo botle ba lisele le matla. E rekisoa e le motsoako o nang le thepa ea ho thibela botsofali le ho tsosolosa bophelo.
Setlolo sa rona se thehiloeng limela se etsoa ka ho sebelisa mehato e thata ea taolo ea boleng 'me se latela maemo a holimo a lits'ebetso tsa tlhahiso. Re beha polokeho le boleng ba sehlahisoa sa rona pele, re netefatsa hore se fihlela litlhoko tsa taolo le mangolo a indasteri. Boitlamo bona ba boleng bo ikemiselitse ho theha tšepo le kholiseho ho ts'epo ea sehlahisoa sa rona. Ts'ebetso e akaretsang ea tlhahiso ke e latelang:
Polokelo: Boloka sebakeng se pholileng, se omileng le se hloekileng, Sireletsa mongobo le khanya e tobileng.
Sephutheloana se Seholo: 25kg/moropa.
Nako ea ho etella pele: Matsatsi a 7 kamora odara ea hau.
Bophelo ba Shelofo: Lilemo tse 2.
Tlhokomeliso: Litlhaloso tse ikhethileng le tsona li ka finyelloa.
25kg/khetla
Sephutheloana se matlafalitsoeng
Tšireletso ea thepa
Hlahisa
Ka tlase ho 100kg, Matsatsi a 3-5
Tšebeletso ea ntlo le ntlo e bonolo ho e lata
Ka Leoatleng
Ho feta 300kg, Matsatsi a ka bang 30
Ho hlokahala morekisi oa tumello ea litsebi tsa koung ho tloha koung ho ea koung
Ka Moyeng
100kg-1000kg, Matsatsi a 5-7
Ho hlokahala morekisi oa litsebi oa tumello ea litšebeletso tsa boema-fofane ho tloha boema-fofaneng ho ea boema-fofaneng
Bioway e fumana mangolo a tumello a kang mangolo a USDA le a EU a tlhaho, mangolo a tumello a BRC, mangolo a tumello a ISO, mangolo a tumello a HALAL, le mangolo a tumello a KOSHER.
