I. Selelekela
Phospholipidske likarolo tsa bohlokoa tsa lera la baeloji 'me li phetha karolo ea bohlokoa lits'ebetsong tse fapaneng tsa 'mele. Ho utloisisa sebopeho le tšebetso ea tsona ke ntho ea bohlokoa ho utloisisa ho rarahana ha biology ea lisele le limolek'hule, hammoho le bohlokoa ba tsona bophelong ba batho le maloetseng. Kakaretso ena e akaretsang e ikemiselitse ho phenya-phenya semelo se rarahaneng sa phospholipids, ho hlahloba tlhaloso le sebopeho sa tsona, hammoho le ho totobatsa bohlokoa ba ho ithuta limolek'hule tsena.
A. Tlhaloso le Sebopeho sa Phospholipids
Phospholipids ke sehlopha sa lipids se nang le liketane tse peli tsa acid e mafura, sehlopha sa phosphate le mokokotlo oa glycerol. Sebopeho se ikhethang sa phospholipids se ba nolofalletsa ho etsa lipid bilayer, motheo oa lisele tsa lisele, ka mehatla ea hydrophobic e shebileng ka hare le lihlooho tsa hydrophilic tse shebileng ka ntle. Tokisetso ena e fana ka mokoallo o matla o laolang ho tsamaea ha lintho ho kena le ho tsoa ka seleng, ha o ntse o boela o buisana le mekhoa e sa tšoaneng ea lisele tse kang pontšo le lipalangoang.
B. Bohlokoa ba ho Ithuta Phospholipids
Ho ithuta phospholipids ho bohlokoa ka mabaka a 'maloa. Taba ea pele, ke karolo ea sebopeho le ts'ebetso ea li-membrane tsa lisele, tse susumetsang metsi, ho kenella, le botsitso. Ho utloisisa thepa ea phospholipids ho bohlokoa bakeng sa ho manolla mekhoa e ka tlase ea lits'ebetso tsa cellular joalo ka endocytosis, exocytosis le transduction ea matšoao.
Ho feta moo, phospholipids e na le litlamorao tse kholo ho bophelo bo botle ba motho, haholoholo mabapi le maemo a kang lefu la pelo, mafu a neurodegenerative le metabolic syndromes. Patlisiso ka phospholipids e ka fana ka leseli mabapi le nts'etsopele ea maano a macha a kalafo le mehato ea lijo e shebaneng le litaba tsena tsa bophelo bo botle.
Ho feta moo, ts'ebeliso ea liindasteri le khoebo ea phospholipids libakeng tse kang tsa meriana, phepo e nepahetseng, le biotechnology li totobatsa bohlokoa ba ho ntšetsa pele tsebo ea rona lefapheng lena. Ho utloisisa likarolo le thepa e fapaneng ea phospholipids ho ka lebisa ho nts'etsopele ea lihlahisoa tse ncha le mahlale a nang le litlamorao tse pharalletseng molemong oa bophelo bo botle ba batho le tsoelo-pele ea mahlale.
Ka bokhutšoanyane, boithuto ba phospholipids bo bohlokoa bakeng sa ho manolla mahlale a rarahaneng ka morao ho sebopeho le ts'ebetso ea lisele, ho lekola phello ea bona bophelong ba batho, le ho sebelisa bokhoni ba bona lits'ebetsong tse fapaneng tsa indasteri. Kakaretso ena e akaretsang e ikemiselitse ho fana ka leseli mabapi le mefuta e mengata ea phospholipids le bohlokoa ba tsona mafapheng a lipatlisiso tsa baeloji, bophelo bo botle ba batho le boqapi ba theknoloji.
II. Mesebetsi ea Biological ea Phospholipids
Phospholipids, e leng karolo ea bohlokoa ea lisele, e bapala likarolo tse fapaneng ho boloka sebopeho le tšebetso ea lisele, hammoho le ho ama lits'ebetso tse fapaneng tsa 'mele. Ho utloisisa mesebetsi ea tlhaho ea phospholipids ho fana ka temohisiso ea bohlokoa ba bona ho bophelo bo botle ba batho le mafu.
A. Seabe Sebopehong sa Membrane ea Sele le Mosebetsi
Mosebetsi oa mantlha oa bioloji oa phospholipids ke tlatsetso ea bona sebopehong le ts'ebetsong ea lisele tsa lisele. Phospholipids e theha lipid bilayer, moralo oa motheo oa lisele tsa lisele, ka ho itlhophisa ka mehatla ea bona ea hydrophobic ka hare le lihlooho tsa hydrophilic ka ntle. Sebopeho sena se theha lesela le sa khoneng ho phunyeletsa le laolang phallo ea lintho ho kena le ho tsoa ka seleng, ka tsela eo ho boloka homeostasis ea cellular le ho nolofatsa mesebetsi ea bohlokoa e kang ho nka limatlafatsi, ho ntša litšila, le pontšo ea lisele.
B. Pontšo le Puisano ka Liseleng
Phospholipids e boetse e sebetsa e le likarolo tsa bohlokoa tsa litsela tsa matšoao le puisano ea sele le lisele. Li-phospholipids tse ling, tse kang phosphatidylinositol, li sebetsa e le li-precursors bakeng sa lipontšo tsa limolek'hule (mohlala, inositol trisphosphate le diacylglycerol) tse laolang mekhoa ea bohlokoa ea lisele, ho kenyelletsa le kholo ea lisele, phapang, le apoptosis. Limolek'hule tsena tse tšoaeang li bapala karolo ea bohlokoa mefuteng e fapaneng ea lipontšo tsa intracellular le intercellular, tse susumetsang karabelo e fapaneng ea 'mele le boits'oaro ba cellular.
C. Tlatsetso ho Bophelo bo Botle ba Boko le Mosebetsi oa Kelello
Phospholipids, haholo-holo phosphatidylcholine, le phosphatidylserine, li ngata bokong 'me li bohlokoa bakeng sa ho boloka sebopeho le mosebetsi oa eona. Li-phospholipids li kenya letsoho ho thehoeng le ho tsitsang ha li-membrane tsa neuronal, li thusa ho lokolloa ha methapo ea kutlo le ho li tšoara, 'me li kenya letsoho ho polasetiki ea synaptic, e leng ea bohlokoa bakeng sa ho ithuta le ho hopola. Ho feta moo, phospholipids e bapala karolo ea mekhoa ea methapo ea methapo 'me e kenyelelitsoe ho sebetsana le ho fokotseha ha kelello ho amanang le botsofali le mathata a methapo ea kutlo.
D. Tšusumetso ho Bophelo bo Botle ba Pelo le Mosebetsi oa Pelo
Phospholipids e bonts'itse litlamorao tse kholo ho bophelo bo botle ba pelo le ts'ebetso ea pelo. Li ameha sebopehong le tšebetsong ea lipoprotein, tse tsamaisang k'holeseterole le lipids tse ling maling. Phospholipids ka har'a lipoprotein li kenya letsoho ho tsitsang le tšebetsong ea tsona, li susumetsa metabolism ea lipid le k'holeseterole homeostasis. Ho feta moo, li-phospholipids li 'nile tsa ithutoa bakeng sa bokhoni ba tsona ba ho fetola boemo ba lipids tsa mali le ho fokotsa kotsi ea mafu a pelo, ho totobatsa liphello tsa bona tsa phekolo ho laola bophelo bo botle ba pelo.
E. Kenyeletso ho Lipid Metabolism le Tlhahiso ea Matla
Phospholipids ke karolo ea bohlokoa ho metabolism ea lipid le tlhahiso ea matla. Ba kenya letsoho ho qaleng le ho putlama ha lipids, ho kenyeletsoa triglycerides le cholesterol, 'me ba phetha karolo ea bohlokoa ho tsamaiseng le ho boloka lipid. Phospholipids e boetse e kenya letsoho mosebetsing oa mitochondrial le tlhahiso ea matla ka ho kenya letsoho ho phosphorylation ea oxidative le ketane ea lipalangoang tsa elektronike, e totobatsang bohlokoa ba tsona ho metabolism ea matla a cellular.
Ka kakaretso, mesebetsi ea bioloji ea phospholipids e na le likarolo tse ngata 'me e akaretsa likarolo tsa eona sebopeho le ts'ebetso ea lera la sele, ho fana ka lipontšo le puisano ka liseleng, tlatsetso ho bophelo bo botle ba boko le ts'ebetso ea kelello, phello ea bophelo bo botle ba pelo le ts'ebetso ea pelo, le ho kenya letsoho ho lipid metabolism le matla. tlhahiso. Kakaretso ena e felletseng e fana ka kutloisiso e tebileng ea mesebetsi e fapaneng ea bioloji ea phospholipids le litlamorao tsa eona bakeng sa bophelo bo botle ba motho le bophelo bo botle.
III. Melemo ea Bophelo bo Botle ba Phospholipids
Phospholipids ke likarolo tsa bohlokoa tsa lisele tse nang le likarolo tse fapaneng tsa bophelo bo botle ba motho. Ho utloisisa melemo ea bophelo bo botle ba phospholipids ho ka fana ka leseli mabapi le ts'ebeliso ea bona ea kalafo le phepo e nepahetseng.
Liphello ho Maemo a Cholesterol
Phospholipids e bapala karolo ea bohlokoa ho metabolism ea lipid le lipalangoang, tse amang ka kotloloho maemo a k'holeseterole 'meleng. Liphuputso li bonts'itse hore phospholipids e khona ho laola metabolism ea k'holeseterole ka ho ama sebopeho, ho monya le ho ntša k'holeseterole. Ho tlalehoa hore phospholipids e thusa ho emulsification le ho qhibiliha ha mafura a jeoang, ka hona ho nolofatsa ho monya ha k'holeseterole ka maleng. Ho feta moo, phospholipids e ameha ho thehoeng ha high-density lipoproteins (HDL), tse tsejoang ka karolo ea tsona ea ho tlosa k'holeseterole e feteletseng maling, kahoo e fokotsa kotsi ea atherosclerosis le mafu a pelo. Bopaki bo fana ka maikutlo a hore phospholipids e ka ba le monyetla oa ho ntlafatsa boemo ba lipid le ho kenya letsoho ho boloka boemo ba cholesterol e phetseng hantle 'meleng.
Lintho tsa Antioxidative
Phospholipids e bonts'a thepa ea antioxidative e tlatsetsang liphellong tsa bona tse molemo bophelong bo botle. E le likarolo tsa bohlokoa tsa lisele tsa cellular, phospholipids e kotsing ea ho senyeha ha oxidative ka li-radicals tsa mahala le mefuta ea oksijene e sebetsang. Leha ho le joalo, li-phospholipids li na le matla a tlhaho a antioxidative, a sebetsa e le li-scavenger tsa li-radicals tsa mahala le ho sireletsa lisele khatellong ea oxidative. Liphuputso li bontšitse hore phospholipids tse khethehileng, tse kang phosphatidylcholine le phosphatidylethanolamine, li ka fokotsa tšenyo ea oxidative le ho thibela lipid peroxidation. Ho feta moo, phospholipids e kentse letsoho ho ntlafatsa ts'ireletso ea antioxidant ka har'a lisele, ka hona e fana ka tšusumetso e sireletsang khahlanong le tšenyo ea oxidative le li-pathologies tse amanang le tsona.
Likopo tse ka 'nang tsa etsahala tsa Phekolo le Phepo
Melemo e ikhethang ea bophelo bo botle ba phospholipids e hlahisitse thahasello lits'ebetsong tsa bona tsa kalafo le phepo e nepahetseng. Ho ntse ho hlahlojoa liphekolo tse thehiloeng ho phospholipid bakeng sa bokhoni ba tsona ba ho laola mathata a amanang le lipid, joalo ka hypercholesterolemia le dyslipidemia. Ho feta moo, li-phospholipids li bonts'itse ts'episo ea ho khothaletsa bophelo bo botle ba sebete le ho ts'ehetsa ts'ebetso ea sebete, haholo maemong a amanang le metabolism ea hepatic lipid le khatello ea oxidative. Lisebelisoa tsa phepo ea phospholipids li 'nile tsa hlokomeloa sebakeng sa lijo tse sebetsang hantle le li-supplement tsa lijo, moo lihlahisoa tse nang le phospholipid tse ngata li ntseng li ntlafatsoa ho ntlafatsa lipid assimilation, ho khothalletsa bophelo bo botle ba pelo, le ho tšehetsa bophelo bo botle ka kakaretso.
Qetellong, melemo ea bophelo bo botle ea phospholipids e kenyelletsa litlamorao tsa bona maemong a cholesterol, thepa ea antioxidative, le ts'ebeliso ea bona ea kalafo le phepo e nepahetseng. Ho utloisisa likarolo tse ngata tsa phospholipids ho boloka physiological homeostasis le ho fokotsa kotsi ea mafu ho fana ka leseli la bohlokoa mabapi le bohlokoa ba tsona ho holiseng bophelo bo botle ba batho le bophelo bo botle.
IV. Mehloli ea Phospholipids
Phospholipids, e le likarolo tsa bohlokoa tsa lipid tsa lisele tsa cellular, li bohlokoa bakeng sa ho boloka botsitso ba sebopeho le tšebetso ea lisele. Ho utloisisa mehloli ea phospholipids ke ntho ea bohlokoa ka ho fetisisa ho ananela bohlokoa ba bona ho phepo e nepahetseng le lits'ebetsong tsa indasteri.
A. Mehloli ea Lijo
Mehloli ea Lijo: Phospholipids e ka fumanoa mehloling e fapaneng ea lijo, 'me mehloli e meng e ruileng ka ho fetisisa e le yolk ea mahe, nama ea setho le linaoa tsa soya. Li-yolk tsa mahe li ngata haholo phosphatidylcholine, mofuta oa phospholipid, ha soya e na le phosphatidylserine le phosphatidylinositol. Mehloli e meng ea lijo ea phospholipids e kenyelletsa lihlahisoa tsa lebese, matokomane le peo ea soneblomo.
Bohlokoa ba Likokoana-hloko: Li-phospholipids tsa lijo li bohlokoa bakeng sa phepo ea batho 'me li phetha karolo ea bohlokoa lits'ebetsong tse fapaneng tsa 'mele. Hang ha e kenngoe, phospholipids e ea siloa ebe e kenngoa ka maleng a manyenyane, moo e sebetsang e le lisebelisoa tsa ho haha membrane ea lisele tsa 'mele le ho kenya letsoho ho theheng le ho sebetsa ha likaroloana tsa lipoprotein tse tsamaisang k'holeseterole le triglycerides.
Liphello tsa Bophelo bo Botle: Lipatlisiso li bontšitse hore phospholipids ea lijo e ka 'na ea e-ba le melemo ea bophelo bo botle, ho kenyelletsa le ho ntlafatsa ts'ebetso ea sebete, ho tšehetsa bophelo bo botle ba boko, le ho kenya letsoho ho bophelo bo botle ba pelo. Ho feta moo, li-phospholipids tse nkiloeng mehloling ea leoatle, joalo ka oli ea krill, li fumane tlhokomelo bakeng sa thepa ea tsona e ka bang khahlanong le ho ruruha le antioxidant.
B. Mehloli ea Liindasteri le Meriana
Indasteri Extraction: Phospholipids le tsona li fumanoa mehloling ea indasteri, moo li ntšoang lihlahisoa tsa tlhaho tse kang soya, peo ea soneblomo le peō ea rape. Joale phospholipids tsena li sebetsoa le ho sebelisoa lits'ebetsong tse fapaneng tsa indasteri, ho kenyelletsa tlhahiso ea li-emulsifiers, stabilizers, le li-encapsulation agents bakeng sa indasteri ea lijo, ea meriana le ea litlolo.
Lisebelisoa tsa Meriana: Phospholipids e bapala karolo ea bohlokoa indastering ea meriana, haholo-holo lits'ebetsong tsa phano ea lithethefatsi. Li sebelisoa e le li-excipient ha ho etsoa litsamaiso tsa phepelo ea lithethefatsi tse thehiloeng ho lipid ho ntlafatsa bioavailability, botsitso le sepheo sa metsoako ea meriana. Ntle le moo, li-phospholipids li 'nile tsa hlahlojoa bakeng sa bokhoni ba tsona ba ho nts'etsapele lijana tse ncha tsa lithethefatsi bakeng sa phepelo e reriloeng le tokollo e tsitsitseng ea kalafo.
Bohlokoa ho Indasteri: Ts'ebeliso ea liindasteri ea phospholipids e fetela ka nqane ho meriana ho kenyelletsa ts'ebeliso ea eona tlhahisong ea lijo, moo e sebetsang e le li-emulsifiers le li-stabilizers lijong tse fapaneng tse phehiloeng. Phospholipids e boetse e sebelisoa tlhahisong ea tlhokomelo ea botho le lihlahisoa tsa litlolo, moo li tlatsetsang botsitso le ts'ebetsong ea metsoako e kang litlolo, litlolo le liposomes.
Qetellong, li-phospholipids li tsoa mehloling ea lijo le ea indasteri, li bapala karolo ea bohlokoa phepong ea batho, bophelo bo botle le lits'ebetsong tse fapaneng tsa indasteri. Ho utloisisa mehloli e fapaneng le ts'ebeliso ea phospholipids ke habohlokoa ho ananela bohlokoa ba bona ho phepo e nepahetseng, bophelo bo botle le indasteri.
V. Lipatlisiso le Likopo
A. Mekhoa ea Hona joale ea Lipatlisiso ka Phospholipid
Saense Patlisiso ea hajoale ho mahlale a phospholipid e akaretsa lihlooho tse ngata tse shebaneng le ho utloisisa sebopeho, tšebetso le likarolo tsa phospholipid lits'ebetsong tse fapaneng tsa tlhaho. Mekhoa ea morao-rao e kenyelletsa ho batlisisa likarolo tse ikhethileng tseo lihlopha tse fapaneng tsa phospholipid li li bapalang ho bonts'a lisele, matla a membrane le metabolism ea lipid. Ho feta moo, ho na le thahasello e kholo ea ho utloisisa hore na liphetoho tse teng sebopehong sa phospholipid li ka ama physiology ea lisele le 'mele, hammoho le nts'etsopele ea mekhoa e mecha ea tlhahlobo ea ho ithuta phospholipid maemong a lisele le limolek'hule.
B. Likopo tsa Liindasteri le Litlhare
Phospholipids e fumane lits'ebetso tse ngata tsa indasteri le tsa meriana ka lebaka la thepa ea tsona e ikhethang ea 'mele le ea lik'hemik'hale. Lefapheng la indasteri, li-phospholipids li sebelisoa e le li-emulsifiers, stabilizers le li-encapsulating liindasteri tsa lijo, tsa litlolo le tsa tlhokomelo ea motho. Litlhare, li-phospholipids li sebelisoa haholo lits'ebetsong tsa phano ea lithethefatsi, ho kenyeletsoa liposomes le lipid-based formulations, ho matlafatsa ho qhibiliha le bioavailability ea lithethefatsi. Tšebeliso ea phospholipids lits'ebetsong tsena e ekelitse phello e ka bang teng liindastering tse fapaneng haholo.
C. Litaelo le Liphephetso tsa Bokamoso Lipatlisisong tsa Phospholipid
Bokamoso ba lipatlisiso tsa phospholipid bo na le ts'episo e kholo, ka litataiso tse ka bang teng ho kenyelletsa nts'etsopele ea lisebelisoa tse ncha tse thehiloeng phospholipid bakeng sa ts'ebeliso ea biotechnological le nanotechnological, hammoho le ho hlahlojoa ha phospholipids e le liphofu bakeng sa mehato ea kalafo. Liphephetso li tla kenyelletsa ho rarolla mathata a amanang le scalability, reproducibility, le theko e tlaase ea lihlahisoa tse thehiloeng ho phospholipid. Ho feta moo, ho utloisisa litšebelisano tse rarahaneng pakeng tsa phospholipids le likarolo tse ling tsa lisele tsa cellular, hammoho le mesebetsi ea tsona mekhoeng ea mafu, e tla ba sebaka sa bohlokoa sa lipatlisiso tse tsoelang pele.
D.Phospholipid LiposomalLihlahisoa tsa serial
Lihlahisoa tsa phospholipid liposomal ke karolo ea bohlokoa ea ho tsepamisa maikutlo lits'ebetsong tsa meriana. Liposomes, tseo e leng li-vesicles tse chitja tse entsoeng ka li-bilayers tsa phospholipid, li ithutile haholo joalo ka mekhoa e ka bang teng ea phepelo ea lithethefatsi. Lihlahisoa tsena li fana ka melemo e kang bokhoni ba ho kenyelletsa lithethefatsi tsa hydrophobic le hydrophilic, ho lebisa lisele kapa lisele tse itseng, le ho fokotsa litla-morao tsa lithethefatsi tse itseng. Lipatlisiso tse tsoelang pele le nts'etsopele li ikemiselitse ho ntlafatsa botsitso, matla a ho jara lithethefatsi, le bokhoni ba ho lebisa tlhokomelo ea lihlahisoa tsa liposomal tse thehiloeng ho phospholipid bakeng sa mekhoa e mengata ea phekolo.
Tlhaloso ena e felletseng e fana ka leseli mabapi le lefapha le ntseng le tsoela pele la lipatlisiso tsa phospholipid, ho kenyeletsoa mekhoa ea hajoale, lits'ebetso tsa indasteri le tsa meriana, tataiso le liphephetso tsa nako e tlang, le nts'etsopele ea lihlahisoa tsa liposomal tse thehiloeng ho phospholipid. Tsebo ena e totobatsa litlamorao le menyetla e fapaneng e amanang le phospholipids mafapheng a fapaneng.
VI. Qetello
A. Kakaretso ea Liphuputso tsa Bohlokoa
Phospholipids, joalo ka likarolo tsa bohlokoa tsa lera la tlhaho, li bapala karolo ea bohlokoa ho boloka sebopeho le tšebetso ea lisele. Lipatlisiso li senotse likarolo tse fapaneng tsa phospholipid ho pontso ea lisele, matla a membrane le metabolism ea lipid. Lihlopha tse khethehileng tsa phospholipids li fumanoe li na le ts'ebetso e ikhethileng ka har'a lisele, tse susumetsang lits'ebetso tse joalo ka phapang ea lisele, ho ata, le apoptosis. Ho feta moo, tšebelisano e rarahaneng lipakeng tsa phospholipids, lipids tse ling le liprotheine tsa membrane e hlahile e le sesupo sa mantlha sa tšebetso ea lisele. Ho feta moo, phospholipids e na le ts'ebeliso ea bohlokoa ea indasteri, haholo tlhahisong ea li-emulsifiers, stabilizers, le litsamaiso tsa phepelo ea lithethefatsi. Ho utloisisa sebopeho le tšebetso ea phospholipids ho fana ka leseli mabapi le ts'ebeliso ea bona ea kalafo le indasteri.
B. Liphello Bakeng sa Bophelo bo Botle le Indasteri
Kutloisiso e felletseng ea phospholipids e na le litlamorao tse kholo ho bophelo bo botle le indastering. Boemong ba bophelo bo botle, phospholipids e bohlokoa bakeng sa ho boloka botšepehi le ts'ebetso ea lisele. Ho se leka-lekane ha sebopeho sa phospholipid ho amahanngoa le mafu a fapaneng, ho kenyelletsa mafu a metabolism, mafu a neurodegenerative le mofets'e. Ka hona, mehato e reretsoeng ho fetola phospholipid metabolism le ts'ebetso e ka ba le monyetla oa ho phekola. Ho feta moo, ts'ebeliso ea phospholipids lits'ebetsong tsa phepelo ea lithethefatsi e fana ka mekhoa e ts'episang ea ho ntlafatsa ts'ebetso le polokeho ea lihlahisoa tsa meriana. Lefapheng la indasteri, li-phospholipids li bohlokoa tlhahisong ea lihlahisoa tse fapaneng tsa bareki, ho kenyeletsoa li-emulsions tsa lijo, litlolo le litlhahlobo tsa meriana. Ho utloisisa likamano tsa sebopeho le ts'ebetso ea phospholipids ho ka tsamaisa boqapi liindastering tsena, ho lebisa ho nts'etsopele ea lihlahisoa tse ncha tse nang le botsitso bo ntlafalitsoeng le bioavailability.
C. Menyetla ea Lipatlisiso tse Tsoelang Pele le Ntlafatso
Patlisiso e tsoelang pele ea saense ea phospholipid e fana ka mekhoa e mengata ea lipatlisiso le nts'etsopele. Sebaka se seng sa bohlokoa ke ho hlakisoa ha mekhoa ea limolek'hule e thehiloeng ho kenya letsoho ha phospholipids litseleng tsa matšoao a lisele le mekhoa ea mafu. Tsebo ena e ka sebelisoa ho nts'etsapele liphekolo tse lebisitsoeng tse tsamaisang phospholipid metabolism molemong oa kalafo. Ho feta moo, lipatlisiso tse ling mabapi le tšebeliso ea phospholipids joalo ka likoloi tse tsamaisang lithethefatsi le nts'etsopele ea litlhare tse thehiloeng ho lipid li tla ntšetsa pele lefapha la meriana. Lefapheng la indasteri, liteko tse tsoelang pele tsa lipatlisiso le nts'etsopele li ka tsepamisa maikutlo ho ntlafatseng lits'ebetso tsa tlhahiso le ts'ebeliso ea lihlahisoa tse thehiloeng ho phospholipid ho fihlela litlhoko tsa mebaraka e fapaneng ea bareki. Ho feta moo, ho hlahloba mehloli ea phospholipids e tsitsitseng le e se nang tikoloho bakeng sa tšebeliso ea indasteri ke sebaka se seng sa bohlokoa bakeng sa nts'etsopele.
Ka hona, tlhahlobo e felletseng ea mahlale a phospholipid e totobatsa bohlokoa ba bohlokoa ba phospholipid ts'ebetsong ea cellular, bokhoni ba bona ba kalafo ho tsa bophelo bo botle, le lits'ebetso tsa bona tse fapaneng tsa indasteri. Phuputso e tsoelang pele ea lipatlisiso tsa phospholipid e fana ka menyetla e thabisang ea ho sebetsana le mathata a amanang le bophelo bo botle le ho khanna boqapi liindastering tse fapaneng.
Litšupiso:
Vance, DE, & Ridgway, ND (1988). methylation ea phosphatidylethanolamine. Tsoelo-pele ho Lipatlisiso tsa Lipid, 27 (1), 61-79.
Cui, Z., Houweling, M., & Vance, DE (1996). Polelo ea phosphatidylethanolamine N-methyltransferase-2 ho McArdle-RH7777 hepatoma cell restructure intracellular phosphatidylethanolamine le triacylglycerol matamo. Journal of Biological Chemistry, 271(36), 21624-21631.
Hannun, YA, & Obeid, LM (2012). Li-ceramide tse ngata. Journal of Biological Chemistry, 287(23), 19060-19068.
Kornhuber, J., Medlin, A., Bleich, S., Jendrossek, V., Henlin, G., Wiltfang, J., & Gulbins, E. (2005). Mosebetsi o phahameng oa acid sphingomyelinase khatellong e kholo ea maikutlo. Journal of Neural Transmission, 112 (12), 1583-1590.
Krstic, D., & Knuesel, I. (2013). Ho tsebahatsa mokhoa o bakang lefu la Alzheimer le hlahang morao tjena. Tlhaho e Hlahlobisisa Neurology, 9 (1), 25-34.
Jiang, XC, Li, Z., & Liu, R. (2018). Andreotti, G, Ho Boeletsa Khokahano pakeng tsa Phospholipids, Ho ruruha le Atherosclerosis. Clinical Lipidology, 13, 15-17.
Halliwell, B. (2007). Biochemistry ea khatello ea oxidative. Liphetoho tsa Mokhatlo oa Biochemical, 35 (5), 1147-1150.
Lattka, E., Illig, T., Heinrich, J., & Koletzko, B. (2010). Na li-acid tse mafura lebeseng la motho li sireletsa botenya? International Journal of Obesity, 34 (2), 157-163.
Cohn, JS, & Kamili, A. (2010). Wat, E, & Adeli, K, Likarolo tse hlahang tsa proprotein convertase subtilisin/kexin mofuta oa 9 inhibition ho lipid metabolism le atherosclerosis. Litlaleho tsa Hona joale tsa Atherosclerosis, 12 (4), 308-315.
Zeisel SH. Choline: karolo ea bohlokoa nakong ea kholo ea lesea le litlhoko tsa lijo ho batho ba baholo. Annu Rev Nutr. 2006;26:229-50. doi: 10.1146/annurev.nutr.26.061505.111156.
Liu L, Geng J, Srinivasarao M, le ba bang. Phospholipid eicosapentaenoic acid-enriched phospholipids ho ntlafatsa ts'ebetso ea neurobehavioral ho likhoto tse latelang kotsi ea boko ea neonatal hypoxic-ischemic. Pediatr Res. 2020;88(1):73-82. doi: 10.1038/s41390-019-0637-8.
Garg R, Singh R, Manchanda SC, Singla D. Karolo ea mekhoa e mecha ea ho fana ka lithethefatsi e sebelisang nanostars kapa nanospheres. South Afr J Bot. 2021;139(1):109-120. doi: 10.1016/j.sajb.2021.01.023.
Kelley, EG, Albert, AD, & Sullivan, MO (2018). Membrane lipids, Eicosanoids, le Synergy of Phospholipid Diversity, Prostaglandins, le Nitric Oxide. Handbook of Experimental Pharmacology, 233, 235-270.
van Meer, G., Voelker, DR, & Feigenson, GW (2008). Membrane lipids: moo ba leng teng le hore na ba itšoara joang. Litlhahlobo tsa Tlhaho Biology ea Lisele tsa Molek'hule, 9(2), 112-124.
Benariba, N., Shambat, G., Marsac, P., & Cansell, M. (2019). Tsoelo-pele ho Liindasteri Synthesis ea Phospholipids. ChemPhysChem, 20(14), 1776-1782.
Torchilin, VP (2005). Khatelo-pele ea morao-rao ka liposomes e le bajari ba meriana. Litlhahlobo tsa Tlhaho Ho Sibolloa ha Lithethefatsi, 4 (2), 145-160.
Brezesinski, G., Zhao, Y., & Gutberlet, T. (2021). Likopano tsa Phospholipid: topology ea sehlopha sa lihlooho, tefo, le ho ikamahanya le maemo. Maikutlo a Hona Joale ho Colloid & Interface Science, 51, 81-93.
Abra, RM, & Hunt, CA (2019). Liposomal Drug Delivery Systems: Tlhahlobo le Menehelo e tsoang ho Biophysics. Litlhahlobo tsa Lik'hemik'hale, 119 (10), 6287-6306.
Allen, TM, & Cullis, PR (2013). Litsamaiso tsa phepelo ea lithethefatsi tsa Liposomal: ho tloha mohopolong ho isa lits'ebetsong tsa bongaka. Litlhahlobo tse tsoetseng pele tsa Phano ea Lithethefatsi, 65(1), 36-48.
Vance JE, Vance DE. Phospholipid biosynthesis liseleng tsa mammalian. Biochem Cell Biol. 2004;82(1):113-128. doi:10.1139/o03-073
van Meer G, Voelker DR, Feigenson GW. Membrane lipids: moo ba leng teng le hore na ba itšoara joang. Nat Rev Mol Cell Biol. 2008;9(2):112-124. doi:10.1038/nrm2330
Boon J. Karolo ea phospholipids mosebetsing oa liprotheine tsa membrane. Biochim Biophys Acta. 2016;1858(10):2256-2268. doi:10.1016/j.bbamem.2016.02.030
Nako ea poso: Dec-21-2023
