I. Selelekela
Phospholids ke sehlopha sa li-limoid tse bohlokoa tsa membrane ea sele, 'me e na le sebopeho se ikhethang se nang le hlooho ea hydrophphilic. Sebaka sa mofuta oa li-fospholiddd se ba lumella ho theha libili tsa Lipid, e leng motheo oa lisele tsa selembranes. Phospholids e entsoe ka liketane tsa glycerol, liketane tse peli tse mafura, le sehlopha sa phosphate, ka lihlopha tse fapaneng tse hokahaneng le phosphate. Sebopeho sena se fa phospholid e le hore motho a iponne ho inka a le monyane le li-vesile tsa Lipid le maiketsetso a bohlokoa bakeng sa botšepehi le tšebetso ea tlhaho.
Phospholilid bapala Karolo ea Bohlokoa Indastering ea bona e fapaneng ka lebaka la thepa ea bona e ikhethang, ho kenyelletsa le khatello ea maikutlo, le mathata a thata. Indastering ea lijo, phospholids e sebelisoa e le emulfiers le basetsi ba nang le lisebelisoa tse sebetsang, hammoho le metsoako ea phetetso ka lebaka la melemo ea bona ea bophelo bo botle. Ka litlolo, phospholipids li sebelisetsoa thepa ea tsona e amohelang le e mongobo, le bakeng sa ho ntlafatsa phallo ea metsoako e mafolofolo ho skincare le lihlahisoa tsa tlhokomelo. Ntle le moo, phospholidids e na le lits'ebetso tsa bohlokoa tsa meriana, haholo-holo lits'ebetsong le bokhoni ba bona ba ho kenya lithethefatsi ka kotloloho 'meleng.
II. Karolo ea phospholids ka lijo
A. Motheo oa sebopeho le ho fetola thepa
Phospholids e sebeletsa e le emlusifers tsa bohlokoa indastering ea lijo ka lebaka la tlhaho ea bona ea tlhaho. Sena se ba lumella ho kenella ka metsi le oli ka bobeli, ho li ntlafatsa ho feta tse thatafatsang, tse kang mayoniing, le lihlahisoa tse fapaneng tsa lebese. Hlooho ea molamu ea hydrophilic ea molek'hule ea phospholid e hoheloang ke metsi, ha mehatla ea hydrophobic e ebutiloe, e bakoang ke sebopeho se tsitsitseng pakeng tsa oli le metsi. Thepa ena e thusa ho qoba karohano le ho boloka ho tsamaisoa ka mefuta e tšoanang lihlahisoa tsa lijo.
B. Sebelisa ts'ebetsong ea lijo le tlhahiso
Phospholids e sebelisoa ts'ebetsong ea lijo bakeng sa thepa ea bona e sebetsang, ho kenyelletsa bokhoni ba bona ba ho fetola litšoantšo, 'me u fane ka botsitso ho litho tsa lijo. Hangata ba sebetsa tlhahiso ea thepa e apetsoeng, confectionery le lihlahisoa tsa lebese ho ntlafatsa bophelo ba boleng le se selfe sa lihlahisoa tsa ho qetela. Ntle le moo, phospholilids e sebelisoa e le baetsi ba likhoho ts'ebetsong ea nama, likhoho tsa likhoho le lihlahisoa tsa lijo tsa leoatleng.
C. Melemo ea Bophelo le Likopo tsa phepo e nepahetseng
Phospholins e kenya letsoho boleng ba phepo e nepahetseng ea lijo tse nang le mehloli ea moruo e mengata, joalo ka mahe, soya le lihlahisoa tsa lebese le lihlahisoa tsa lebese. Melemo ea bona eo ba ka bang le melemo ea bophelo bo botle, ho kenyelletsa karolo eo ba e etsang ka sebopeho le ts'ebetsong, hammoho le bokhoni ba bona ba ho tšehetsa bophelo ba boko le mosebetsi oa kelello. Phospholids le eona e fumaneha hape ka bokhoni ba bona ba ho ntlafatsa bophelo ba metabolism le pelo tsa pelo tsa pelo.
III. Likopo tsa phospholids ho litlolo
A. Ho susumetsa le ho ba le litlamorao
Phospholilids e sebelisoa haholo ka litlolo le lihlahisoa tsa tlhokomelo tsa motho bakeng sa litlamorao tsa tsona tse matlafatsang le tse mongobo. Ka lebaka la tlhaho ea bona ea botho, phospholilids ba khona ho theha emumuls e tsitsitseng, e lumella metsoako ea metsi le oli ho kopanya le ho li thibela ka matso a boreleli, a tšoanang. Ntle le moo, sebopeho se ikhethileng sa lifospholids se ba nolofalletsa ho etsisa letlalong la tlhaho le ho thibela tahlehelo ea metsi le ho thibela ho oma.
Phospholids e kang Lecithin e sebelisitsoe e le li-emumoriles le mongobo lihlahisoa tse fapaneng tsa litlolo le tsa strams, litlolo le mahlaseli a letlalo. Bokhoni ba bona ba ho ntlafatsa sebopeho, ho utloa le hore lihlahisoa tsa lihlahisoa tsena li ba etsa metsoako ea bohlokoa indastering ea litlolo.
B. Ho ntlafatsa ho tsamaisoa ha metsoako e mafolofolo
Phospholids e bapala karolo ea bohlokoa ho ntlafatsa phallo ea lisebelisoa tse mafolofolo ho likhathatso tsa litlolo le tsa skincare. Bokhoni ba bona ba ho theha liposomes, li-proction tse entsoeng ka libiespholipid tsa phospholipid, lumella ho kenella le metsoako e mengata, tse kang livithamini, li-antiestuns tse ling tse molemo. Ho kenella hona ho thusa ho ntlafatsa botsitso, bianalililical, le ho fana ka tšebetso ea bona ka lihlahisoa tsena, ho ntlafatsa katleho ea bona ho litlolo le matsoho.
Ho feta moo, litsamaiso tsa phepelo tse thehiloeng ho phospholidid li sebelisoa ho hlola mathata a ho fana ka metsoako e sebetsang ea ho fana ka metsoako e sebetsang, e li etsa hore li hlahisoe bajara tse fapaneng. Mefuta ea Lipospholids e sebelisitsoe haholo ho li-anti-ralice, le lihlahisoa tsa tokiso ea letlalo, moo li ka fanang ka lisebelisoa tsa mafolofolo ka katleho le likepe tse sebetsang.
C. Karolo ho Skincare le tsa tlhokomelo ea tlhokomelo
Mehala ea lifospholiliks play lihlahisoa tsa tlhokomelo ea matsoho le tlhokomelo ea motho ka mong, li kenya tšebetsong ts'ebetso ea bona le katleho. Ntle le ho hloka thepa ea hae e matlafatsang, e matlafatsang le thepa e ntlafatsang, phospholids le eona e fana ka melemo e joalo ka ho ikamahanya le maemo a letlalo, tšireletso le ho li lokisa. Limolek'hule tsena tse mpe li ka thusa ho ntlafatsa boiphihlelo ba maikutlo le ts'ebetso ea lihlahisoa tsa litlolo, e ba etsang metsoako e tsebahalang ka litlhahiso tsa skincare.
Ho kenyelletsoa ha phospholids ho Skincare le lisebelisoa tsa tlhokomelo e nyolohetse Boitšoaro ba bona ba tlhaho bo ba lumelle ho rarolla litlhoko tse fapaneng le tsa tlhokomelo ea moriri, ho fana ka melemo e meng ea litlolo le bareki ba kalafo ho bareki.
IV. Litheolelo tsa phospholids ho pharmaceuticals
A. Ho tsamaisa lithethefatsi le ho theha
Phospholilid o bapala karolo ea bohlokoa ho meriana ea litlhare tsa meriana le ho theha kalafo ka lebaka la tlhaho ea bona ea ho ba le mathata le matsetsi a mangata a hydrophobic le hydrophilic Thepa ena e thusa phospholids ho ntlafatsa tharollo, ho tsitsa le ho thehoa ha lithethefatsi tse qhibilihang, ho ntlafatsa bokhoni ba bona bakeng sa ts'ebeliso ea kalafo. Litsamaiso tsa phekolo ea lithethefatsi tse thehiloeng ho phospholid le tsona li ka thibela lithethefatsi ho tsoa ho senya, ho lokolla lisele tsa lithethefatsi, le lisele tsa taolo, le litlamorao.
Bokhoni ba phospholids ho theha meaho ea bobolu, e kang Liposomes, ho kenyelletsa le mefuta ea litheko tse fapaneng tsa meriana, ho kenyelletsa le mekhoa ea lithereral, le ea holimo le e kholo ea dofages. Mefuta e thehiloeng lipid, joalo ka ho tsuba, e tiileng ea li-nanoparts, 'me hangata e kenyelletsa litholoana tsa kalafo ea meriana.
B. Sistimation ea li-trasimal tsa lithethefatsi
Litsamaiso tsa Lipe tsa Lipesamal Litšitiso ke mohlala o hlahelletseng oa hore na liforopholipids li sebelisoa joang ho lits'ebetso tsa meriana. Liposome, e entsoe ka li-bilay tsa phospholid, li na le bokhoni ba ho kenya lithethefatsi motheong oa tsona oa mahlouleng, ho fana ka tikoloho ea lithethefatsi. Litsamaiso tsena tsa lithethefatsi li ka tsamaisa ho ntlafatsa ts'ebetso ea mefuta e fapaneng ea lithethefatsi, ho kenyelletsa lithibela-mafu, lithibela-mafu le lisele tse ngata.
Ho se sebetse ha Lipossome ho lumella ho fetoloa ha boholo ba tsona, tefo le motheo oa thepa ho ntlafatsa phetisetso ea lithethefatsi, botsitso. Ho feto-fetoha ha maemo hona ho lebisitse ho nts'etsopele ea lipotlo tse hanyetsang ka bongaka ba likopo tsa kalafo, a hatisa bohlokoa ba mahlale a ho fana ka litlhahlobo tse tsoelang pele.
C. Likopo tse ka bang teng lipatlisisong le kalafong ea bongaka
Phospholids ho na le bokhoni ba lits'ebetso ho lipatlisiso tsa bongaka le kalafong ho feta lits'ebetso tsa phepelo ea lithethefatsi. Mabaka a bona a ho sebelisana le membrane ea selefouno le ho fetola lits'ebetso tsa lisele li fana ka menyetla ea ho hlahisa maano a phatlalatso. Mekhoa e thehiloeng ho phospholid e hlahisitsoe ka bokhoni ba bona ba ho beha mekhoa e pharaletseng libakeng tse kang kalafo ea mofets'e, le kalafo e pakiloeng
Ho feta moo, phospholipids e hlahlojoa bakeng sa karolo ea bona ea ho lokisa le ho ntlafatsa, boenjiniere ba liphoofolong le pherekano ea li-turning. Tsebo ea tsona ea ho etsisa li-memmbranes tsa tlhaho 'me li sebelisana le phospholids ka mokhoa o tšepisang bakeng sa boiphetetso le kalafo.
V. liphephetso le likarolo tsa ka moso
A. Mehopolo ea Regal le Mehopolo ea Ts'ireletso
Sesebelisoa sa phospholilited ka lijo, litlolo, le meriana ea meriana e mengata ea tšireletso le matšoenyeho a polokeho. Indastering ea lijo, phospholilids e sebelisoa e le emmolferiss, basetsi le lits'ebetso tsa ho tsamaisa metsoako e sebetsang. Mebele e laoloang, e kang tsamaiso ea lijo le ea lithethefatsi (FDA) United States le Europe ea Lijo tse nang le phoospholids. Litlhahlobo tsa polokeho li bohlokoa ho netefatsa hore litlatsetso tsa lijo tsa phospholidid li bolokehile bakeng sa tšebeliso ea maikutlo le ho latela melao.
Indastering ea Li-cosmetics, phospholilids e sebelisoa ka har'a letlalo, ho mo rama, le lihlahisoa tsa letlalo le letlalo la letlalo. Mekhatlo ea morao-rao, joalo ka Melao ea Litlolo tsa European Union le Tsamaiso ea Lithethefatsi (FDA) ea ho beha Lihlahisoa tse nang le phospholids ho netefatsa tšireletso ea bareki. Litlhahlobo tsa polokeho le lithuto tsa tlhaho tsa chefo li etsoa ho lekola profil sa polokeho ea metsoako ea litlolo tsa phospholid.
Likarolong tsa pharmaceut, polokeho ea phospholilids e akaretsa ts'ebeliso ea bona lits'ebetsong tsa lithethefatsi, ho ba bonolo litlhare le li-raricatick tsa meriana. Balaoli, ba kang FDA le FDA e Europe ea Meriana (EMAS Matšoenyeho a polokeho a amanang le phospholilids libakeng tse ling tsa pharmatical li potoloha le chefo e ka bang teng kapa ho lumellana le linthong tsa lithethefatsi.
B. Mekhoa e Meno le Litaba
Tšebeliso ea phospholids lijong, litlolo, le meriana le merimaceutanicals li bonahatsa mekhoa e meng le liphetoho tse ntlafatsang. Indastering ea lijo, tšebeliso ea phospholizalids e le li-emmolizer tsa tlhaho ebile li ntse li batla ho hloekisoa ka lebitso le ntseng le batla ho hloekisoa le metsoako ea tlhaho. Mahlale a ntlafalitsoeng a kang Nanomiculions a tsitsipane ke phospholilids, a ntse a hlahlojoa hore a ntlafatse annoulity le bioavali motle a likarolo tse sebetsang, tse kang metsoako e sebetsang le livithamini.
Indastering ea litlolo, tšebeliso ea phospholids ka mekhoa e tsoetseng pele ea skincare ke mokhoa o hlahelletseng, ka ho tsepamisa likelello tsa metsoako ea lipid le ho lokisa thepa. LITLHAKISO TSE ITHUTOANG LINTHO TSE LING TSE LING TSE LING TSE LING TSA BOPHELO BA LEA LITS'A LIPOSSHOMES
Ka har'a lefapha la meriana, mekhoa e hlahang ho ts'oaro tsa lithethefatsi tsa phospholid e nang le kalafo ea motho e mong. Bareki ba haufi-ufi, ho kenyelletsa le lipid-polymer lipompo tsa lithethefatsi le lingaka tse thehiloeng ho li-coljutictics, ho sebetsana le mathata a ho etsa litsietsi, botsitso le sepheo sa marang-rang.
C. Bontle ba menyetla ea indasteri ea sefapano le menyetla ea ntlafatso
Ho se sebetse hantle ha phospholids ho fana ka menyetla ea ts'ebelisano ea litaba tsa sefapano le nts'etsopele ea lihlahisoa tse ncha tse nchafatsang ka mokhoa o khahlisang oa lijo, litlolo le meriana le meriana. Lithuto tsa indasteri tsa sefapano li ka thusa phapanyetsano ea tsebo, mahlale a bile a mekhoa e metle e amanang le tšebeliso ea phospholides ka likarolo tse fapaneng. Mohlala, setsebi sa phepelo e thehiloeng lipid se tsoang indastering ea meriana e ka phathahana ho ntlafatsa moralo le ts'ebetso ea li-cosmetics.
Ho feta moo, bokhopo ba lijo, litlolo, litlolo le meriana, meriana e lebisa ho nts'etsopele ea lihlahisoa tsa mafutsana tse ratoang ke bophelo bo ratoang ke bophelo bo ratoang ke bophelo bo itseng, le boiketlo le litlhoko tsa botle. Mohlala, linate le cosmecUticals le cosmeceuticals tse amanang le mefong, e hlahisang tharollo ea bophelo bo botle le ka ntle. Lithuto tsena le tsona li khothaletsa menyetla ea ho etsa lipatlisiso le tse tsoelang pele tse rerang ho phutha lipehelo tse ka bang teng tsa mapolanka tse nang le liforomo.
VI. Sephetho
A. Recap ea ho fapanyetsana le bohlokoa ba phospholids
Phospholilins o bapala karolo ea bohlokoa indastering ea bohlokoahali, o fana ka lits'ebetso tse fapaneng lijong, litlolo le merero ea meriana. Sebopeho sa bona sa lik'hemik'hale se ikhethileng, se kenyelletsang libaka tsa hae tsa hydrophilic le tsa hydrophilic, li thusa ho sebetsa e le emmorifurs tsa lisebelisoa tse sebetsang. Indastering ea lijo, phospholips e kenya letsoho ho tsitsitseng le sebopeho sa lijo tse sebetsoang, ha li fana ka lihlahisoa tsa lihlahisoa tsa skincare. Ho feta moo, indasteri ea pharmacceceles e pharalletseng phospholids ka litsamaiso tsa lipalesa tsa lipalesa, mekhoa ea lipelo e le tsebiso ea meriana ea ho ntlafatsa le libaka tse qaqileng tsa ketso.
B. Litšebeletso tsa lipatlisiso tse tlang le lits'ebetso tsa indasteri
Kaha lipatlisiso tse ntseng li le tšimong ea phospholilid li ntse li tsoela pele, ho na le litlamorao tse 'maloa bakeng sa lithuto tsa nako e tlang le lits'ebetso tsa indasteri. Pele, patlisiso e tsoelang pele ka polokeho, e sebetsa hantle le e ka bang le li-syneries tse teng lipakeng tsa lihlahisoa tsa methapo le metsoako e meng e ka phahamisetsa litlhoko tse mpe tsa bareki. Ntle le moo, ho hlahloba ts'ebeliso ea phospholikid ho semeketeng sa theknoloji ea mahlale, le litlolo tse thehiloeng lijong, litlolo le mekhabiso. Patlisiso ena e ka lebisa ho bōpi ea mehopolo e ncha ea sehlahisoa e fanang ka ts'ebetso e ntlafalitsoeng le katleho.
Ho tsoa maemong a indasteri, bohlokoa ba phospholipids likopo tse fapaneng ba sebelisa bohlokoa ba ho ntšoa le ho sebelisa hape ho indasteri e tsoelang pele. Ka tlhoko e 'ngoe e ntseng e hola bakeng sa metsoako ea tlhaho le e sebetsang, ho kopana ha metsoako ea phospholids lijong, litlolo le mebusi e tsitsitseng e fana ka khetho ea lintho tsa boleng bo phahameng. Ntle le moo, lits'ebetso tsa indasteri ea bokamoso li ka kenyelletsa tšebelisano ea melaoana ea sefapano, moo litlolo, li-cosmeticcy li ka fetolang bophelo bo botle le botle.
Qetellong, ho se sebetse ha phospholids le bohlokoa ba tsona lijong, litlolo le li-meriana li etsa hore likarolo tsa bohlokoa tsa lihlahisoa tse ngata. Monyetla oa bona oa lipatlisiso tsa kamoso le likopo tsa indasteri li thunya tsela ea ho tsoela pele ka mekhatlo e metšo le mekhoeng ea lefatše, 'maraka oa lefatše o ile oa tšela indasteri ea lefatše.
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Nako ea poso: Dec-27- 27-023
