Tšusumetso ea Phospholipids ho Bophelo bo Botle ba Boko le Mosebetsi oa Kelello

I. Selelekela
Li-phospholipids ke likarolo tsa bohlokoa tsa lisele tsa lisele, 'me li bapala karolo ea bohlokoa ho boloka botšepehi le tšebetso ea lisele tsa boko. Ba theha lipid bilayer e pota-potileng le ho sireletsa li-neurone le lisele tse ling tsa boko, e leng se tlatsetsang mosebetsing o akaretsang oa tsamaiso ea methapo e bohareng. Ho feta moo, li-phospholipids li ameha mekhoeng e fapaneng ea matšoao le lits'ebetso tsa neurotransmission tse bohlokoa bakeng sa ts'ebetso ea boko.

Bophelo bo botle ba boko le ts'ebetso ea kelello ke tsa bohlokoa bakeng sa bophelo bo botle ka kakaretso le boleng ba bophelo. Mekhoa ea kelello e kang mohopolo, tlhokomelo, ho rarolla mathata, le ho etsa liqeto ke karolo ea ts'ebetso ea letsatsi le letsatsi 'me e itšetlehile ka bophelo bo botle le ts'ebetso e nepahetseng ea boko. Ha batho ba ntse ba tsofala, ho boloka ts'ebetso ea kelello ho ba bohlokoa le ho feta, ho etsa hore boithuto ba lintlha tse susumetsang bophelo bo botle ba boko bo be bohlokoa bakeng sa ho sebetsana le phokotso ea kelello e amanang le lilemo le mathata a kelello a kang 'dementia'.

Sepheo sa thuto ena ke ho hlahloba le ho sekaseka phello ea phospholipids ho bophelo bo botle ba boko le ts'ebetso ea kelello. Ka ho batlisisa karolo ea phospholipids ho boloka bophelo bo botle ba boko le ho tšehetsa mekhoa ea kelello, thuto ena e ikemiselitse ho fana ka kutloisiso e tebileng ea kamano pakeng tsa phospholipids le mosebetsi oa boko. Ho feta moo, boithuto bo tla lekola litlamorao tse ka bang teng molemong oa ho kenella le liphekolo tse reretsoeng ho boloka le ho ntlafatsa bophelo bo botle ba boko le ts'ebetso ea kelello.

II. Ho utloisisa Phospholipids

A. Tlhaloso ea phospholipids:
Phospholipidske sehlopha sa lipids tseo e leng karolo e kholo ea lisele tsohle, ho kenyeletsoa le tse bokong. Li entsoe ka molek'hule ea glycerol, li-acid tse peli tsa mafura, sehlopha sa phosphate le sehlopha sa hlooho ea polar. Phospholipids li khetholloa ka tlhaho ea tsona ea li-amphiphilic, ho bolelang hore li na le libaka tse peli tsa hydrophilic (tse khahlang metsi) le hydrophobic (tse thibelang metsi). Thepa ena e lumella li-phospholipids ho theha li-bilayers tsa lipid tse sebetsang e le motheo oa sebopeho sa lisele, ho fana ka mokoallo lipakeng tsa bokahare ba sele le tikoloho ea eona ea kantle.

B. Mefuta ea phospholipids e fumanoang bokong:
Boko bo na le mefuta e mengata ea phospholipids, 'me e ngata haholophosphatidylcholinephosphatidylethanolamine,phosphatidylserine, le sphingomyelin. Li-phospholipids tsena li kenya letsoho linthong tse ikhethang le mesebetsing ea lisele tsa boko. Ka mohlala, phosphatidylcholine ke karolo ea bohlokoa ea lisele tsa methapo ea kutlo, ha phosphatidylserine e ameha ho fetisetsoang ha matšoao le ho lokolloa ha neurotransmitter. Sphingomyelin, phospholipid e 'ngoe ea bohlokoa e fumanoang liseleng tsa boko, e phetha karolo ea ho boloka botšepehi ba li-myelin sheaths tse sireletsang le ho sireletsa methapo ea kutlo.

C. Sebopeho le mosebetsi oa phospholipids:
Sebopeho sa phospholipids se na le sehlopha sa hlooho sa hydrophilic phosphate se kopantsoeng le molek'hule ea glycerol le mehatla e 'meli ea hydrophobic fatty acid. Sebopeho sena sa amphiphilic se lumella phospholipids ho theha lipid bilayers, le lihlooho tsa hydrophilic tse shebileng ka ntle le mehatla ea hydrophobic e shebile ka hare. Tokisetso ena ea phospholipids e fana ka motheo bakeng sa mohlala oa mokelikeli oa mosaic oa lisele tsa lisele, o nolofalletsang ho kenella ka mokhoa o ikhethileng bakeng sa ts'ebetso ea cellular. Ha e le hantle, phospholipids e bapala karolo ea bohlokoa ho boloka botšepehi le ts'ebetso ea lisele tsa boko. Li kenya letsoho ho tsitsiseng le ho phalla ha lisele tsa lisele, li thusa ho tsamaisa limolek'hule ho pholletsa le lera, le ho kenya letsoho lipontšong tsa lisele le puisano. Ho phaella moo, mefuta e itseng ea phospholipids, e kang phosphatidylserine, e 'nile ea amahanngoa le mesebetsi ea kelello le mekhoa ea ho hopola, e totobatsang bohlokoa ba bona ho bophelo bo botle ba boko le ts'ebetso ea kelello.

III. Tšusumetso ea Phospholipids ho Bophelo bo Botle ba Boko

A. Tlhokomelo ea sebopeho sa lisele tsa boko:
Phospholipids e bapala karolo ea bohlokoa ho boloka botsitso ba sebopeho sa lisele tsa boko. E le karolo e kholo ea lisele tsa lisele, phospholipids e fana ka moralo oa motheo bakeng sa meralo le ts'ebetso ea methapo ea kutlo le lisele tse ling tsa boko. Phospholipid bilayer e etsa mokoallo o feto-fetohang le o matla o arolang tikoloho e ka hare ea lisele tsa boko le tikoloho e ka ntle, e laolang ho kena le ho tsoa ha limolek'hule le li-ion. Botšepehi bona ba sebopeho bo bohlokoa bakeng sa ts'ebetso e nepahetseng ea lisele tsa boko, kaha bo thusa ho boloka homeostasis ea intracellular, puisano lipakeng tsa lisele, le phetiso ea matšoao a methapo.

B. Karolo ho phetiso ea methapo ea kutlo:
Phospholipids e kenya letsoho haholo ts'ebetsong ea phepelo ea methapo ea kutlo, e bohlokoa bakeng sa mesebetsi e fapaneng ea kelello joalo ka ho ithuta, mohopolo le taolo ea maikutlo. Puisano ea methapo e itšetlehile ka ho lokolloa, ho phatlalatsoa le ho amoheloa ha li-neurotransmitters ho pholletsa le li-synapses, 'me phospholipids e ameha ka ho toba lits'ebetsong tsena. Mohlala, li-phospholipids li sebetsa e le li-precursor bakeng sa ho qaptjoa ha li-neurotransmitters le ho hlophisa tšebetso ea li-neurotransmitter receptors le lipalangoang. Phospholipids e boetse e ama ho phalla ha metsi le ho phunyeletsa ha lisele tsa lisele, ho susumetsa exocytosis le endocytosis ea li-vesicles tse nang le neurotransmitter le taolo ea phetisetso ea synaptic.

C. Tšireletso khahlanong le khatello ea oxidative:
Boko bo kotsing haholo ho senyeha ha oxidative ka lebaka la tšebeliso e phahameng ea oksijene, maemo a phahameng a acid e mafura a polyunsaturated, le maemo a tlase a ts'ireletso ea antioxidant. Phospholipids, joalo ka likarolo tse kholo tsa lisele tsa boko, li kenya letsoho ts'ireletso khahlanong le khatello ea oxidative ka ho sebetsa e le liphofu le matamo a limolek'hule tsa antioxidant. Li-phospholipids tse nang le metsoako ea antioxidant, joalo ka vithamine E, li bapala karolo ea bohlokoa ho sireletseng lisele tsa boko ho tsoa ho lipid peroxidation le ho boloka lera le ts'epahalo le metsi. Ho feta moo, phospholipids e boetse e sebetsa e le limolek'hule tse bontšang litseleng tsa karabelo ea cellular tse loantšang khatello ea oxidative le ho khothalletsa ho phela ha lisele.

IV. Tšusumetso ea Phospholipids Mosebetsing oa Kelello

A. Tlhaloso ea phospholipids:
Phospholipids ke sehlopha sa lipids e leng karolo e kholo ea lisele tsohle tsa lisele, ho kenyelletsa le tse bokong. Li entsoe ka molek'hule ea glycerol, li-acid tse peli tsa mafura, sehlopha sa phosphate le sehlopha sa hlooho ea polar. Phospholipids li khetholloa ka tlhaho ea tsona ea li-amphiphilic, ho bolelang hore li na le libaka tse peli tsa hydrophilic (tse khahlang metsi) le hydrophobic (tse thibelang metsi). Thepa ena e lumella li-phospholipids ho theha li-bilayers tsa lipid tse sebetsang e le motheo oa sebopeho sa lisele, ho fana ka mokoallo lipakeng tsa bokahare ba sele le tikoloho ea eona ea kantle.

B. Mefuta ea phospholipids e fumanoang bokong:
Boko bo na le mefuta e mengata ea phospholipids, 'me e ngata haholo ke phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, le sphingomyelin. Li-phospholipids tsena li kenya letsoho linthong tse ikhethang le mesebetsing ea lisele tsa boko. Ka mohlala, phosphatidylcholine ke karolo ea bohlokoa ea lisele tsa methapo ea kutlo, ha phosphatidylserine e ameha ho fetisetsoang ha matšoao le ho lokolloa ha neurotransmitter. Sphingomyelin, phospholipid e 'ngoe ea bohlokoa e fumanoang liseleng tsa boko, e phetha karolo ea ho boloka botšepehi ba li-myelin sheaths tse sireletsang le ho sireletsa methapo ea kutlo.

C. Sebopeho le mosebetsi oa phospholipids:
Sebopeho sa phospholipids se na le sehlopha sa hlooho sa hydrophilic phosphate se kopantsoeng le molek'hule ea glycerol le mehatla e 'meli ea hydrophobic fatty acid. Sebopeho sena sa amphiphilic se lumella phospholipids ho theha lipid bilayers, le lihlooho tsa hydrophilic tse shebileng ka ntle le mehatla ea hydrophobic e shebile ka hare. Tokisetso ena ea phospholipids e fana ka motheo bakeng sa mohlala oa mokelikeli oa mosaic oa lisele tsa lisele, o nolofalletsang ho kenella ka mokhoa o ikhethileng bakeng sa ts'ebetso ea cellular. Ha e le hantle, phospholipids e bapala karolo ea bohlokoa ho boloka botšepehi le ts'ebetso ea lisele tsa boko. Li kenya letsoho ho tsitsiseng le ho phalla ha lisele tsa lisele, li thusa ho tsamaisa limolek'hule ho pholletsa le lera, le ho kenya letsoho lipontšong tsa lisele le puisano. Ho phaella moo, mefuta e itseng ea phospholipids, e kang phosphatidylserine, e 'nile ea amahanngoa le mesebetsi ea kelello le mekhoa ea ho hopola, e totobatsang bohlokoa ba bona ho bophelo bo botle ba boko le ts'ebetso ea kelello.

V. Lintlha tse Amang Maemo a Phospholipid

A. Mehloli ea lijo tsa phospholipids
Phospholipids ke likarolo tsa bohlokoa tsa phepo e nepahetseng 'me li ka fumanoa mehloling e fapaneng ea lijo. Mehloli ea mantlha ea lijo tsa phospholipids e kenyelletsa li-yolk tsa mahe, linaoa tsa soya, nama ea setho le lijo tse ling tsa leoatleng tse kang herring, mackerel le salmon. Li-yolk tsa mahe, haholo-holo, li na le phosphatidylcholine e ngata, e leng e 'ngoe ea phospholipids tse ngata ka ho fetisisa bokong le selelekela sa neurotransmitter acetylcholine, e leng ea bohlokoa bakeng sa mohopolo le ts'ebetso ea kelello. Ho phaella moo, linaoa tsa soya ke mohloli oa bohlokoa oa phosphatidylserine, phospholipid e 'ngoe ea bohlokoa e nang le liphello tse molemo mosebetsing oa kelello. Ho etsa bonnete ba hore ho na le phepo e nepahetseng ea mehloli ena ea lijo ho ka kenya letsoho ho boloka maemo a nepahetseng a phospholipid bakeng sa bophelo bo botle ba boko le ts'ebetso ea kelello.

B. Mokhoa oa bophelo le maemo a tikoloho
Mokhoa oa bophelo le maemo a tikoloho a ka ama haholo maemo a phospholipid 'meleng. Ka mohlala, khatello ea kelello e sa foleng le ho pepesehela chefo ea tikoloho ho ka lebisa tlhahisong e eketsehileng ea limolek'hule tse ruruhileng tse amang sebopeho le botšepehi ba lisele tsa lisele, ho kenyeletsa le tse bokong. Ho feta moo, mekhoa ea bophelo e kang ho tsuba, ho noa joala ho tlōla, le lijo tse nang le mafura a mangata le mafura a mangata li ka ama metabolism ea phospholipid hampe. Ka lehlakoreng le leng, ho ikoetlisa kamehla le lijo tse nang le li-antioxidants, omega-3 fatty acids, le limatlafatsi tse ling tsa bohlokoa li ka khothalletsa maemo a phospholipid a phetseng hantle le ho tšehetsa bophelo bo botle ba boko le ts'ebetso ea kelello.

C. Monyetla oa tlatsetso
Ka lebaka la bohlokoa ba phospholipids bophelong ba boko le ts'ebetso ea kelello, ho na le thahasello e ntseng e hola molemong oa tlatsetso ea phospholipid ho ts'ehetsa le ho ntlafatsa maemo a phospholipid. Li-supplement tsa phospholipid, haholo-holo tse nang le phosphatidylserine le phosphatidylcholine tse tsoang mehloling e kang soy lecithin le marine phospholipids, li ithutoe bakeng sa litlamorao tsa tsona tse ntlafatsang kelello. Liteko tsa bongaka li bontšitse hore phospholipid supplementation e ka ntlafatsa mohopolo, tlhokomelo, le lebelo la ts'ebetso ho batho ba baholo le ba baholo. Ho feta moo, li-supplement tsa phospholipid, ha li kopantsoe le omega-3 fatty acids, li bontšitse liphello tsa synergistic ho khothalletsa botsofali bo botle ba boko le ts'ebetso ea kelello.

VI. Lithuto tsa Lipatlisiso le Liphuputso

A. Kakaretso ea Lipatlisiso tse Amanang mabapi le Phospholipids le Bophelo bo Botle ba Boko
Phospholipids, likarolo tsa mantlha tsa sebopeho sa lisele, li bapala karolo ea bohlokoa bophelong ba boko le ts'ebetso ea kelello. Lipatlisiso mabapi le phello ea phospholipids ho bophelo bo botle ba boko li tsepamisitse maikutlo mesebetsing ea tsona ho synaptic plasticity, neurotransmitter function, le ts'ebetso ea kelello ka kakaretso. Liphuputso li batlisisitse litlamorao tsa phospholipids ea lijo, joalo ka phosphatidylcholine le phosphatidylserine, ts'ebetsong ea kelello le bophelo bo botle ba boko mefuteng ea liphoofolo le lithutong tsa batho. Ho feta moo, lipatlisiso li hlahlobile melemo e ka bang teng ea phospholipid supplementation ho khothaletsa ntlafatso ea kelello le ho ts'ehetsa botsofali ba boko. Ho feta moo, lithuto tsa neuroimaging li fane ka leseli mabapi le likamano lipakeng tsa phospholipids, sebopeho sa boko, le khokahanyo ea ts'ebetso, ho fana ka leseli mabapi le mekhoa e ka sehloohong ea phello ea phospholipids ho bophelo bo botle ba boko.

B. Lintlha tsa Bohlokoa le Liqeto tse Tsoang Lithutong
Ntlafatso ea Kelello:Liphuputso tse 'maloa li tlalehile hore phospholipids ea lijo, haholo-holo phosphatidylserine le phosphatidylcholine, e ka ntlafatsa likarolo tse sa tšoaneng tsa ts'ebetso ea kelello, ho akarelletsa le mohopolo, tlhokomelo le lebelo la ho sebetsa. Tekong ea tleliniki e laoloang ka mokhoa o sa reroang, e sa boneng habeli, e laoloang ke placebo, phosphatidylserine supplementation e ile ea fumanoa e ntlafatsa mohopolo le matšoao a ho se tsotelle ha bana, ho fana ka maikutlo a tšebeliso e ka sebelisoang ea phekolo bakeng sa ntlafatso ea kelello. Ka mokhoa o ts'oanang, li-supplement tsa phospholipid, ha li kopantsoe le omega-3 fatty acids, li bontšitse liphello tsa synergistic ho khothalletsa ts'ebetso ea kelello ho batho ba phelang hantle ho pholletsa le lilemo tse fapaneng. Liphuputso tsena li totobatsa bokhoni ba phospholipids e le lisebelisoa tsa kelello.

Sebopeho le Mosebetsi oa Boko:  Lithuto tsa Neuroimaging li fane ka bopaki ba kamano pakeng tsa phospholipids le sebopeho sa boko hammoho le khokahanyo e sebetsang. Mohlala, liphuputso tsa "magnetic resonance spectroscopy" li senotse hore maemo a phospholipid libakeng tse ling tsa boko a amana le ts'ebetso ea kelello le ho fokotseha ha kelello ho amanang le lilemo. Ho feta moo, liphuputso tsa litšoantšo tsa diffusion tensor li bonts'itse phello ea sebopeho sa phospholipid ho botšepehi ba taba e tšoeu, e leng bohlokoa bakeng sa puisano e nepahetseng ea methapo. Liphuputso tsena li fana ka maikutlo a hore phospholipids e bapala karolo ea bohlokoa ho boloka sebopeho sa boko le ts'ebetso ea boko, kahoo e susumetsa bokhoni ba kelello.

Litlamorao ho Botsofali ba Boko:Lipatlisiso ka phospholipids le tsona li na le litlamorao bakeng sa botsofali ba boko le maemo a neurodegenerative. Liphuputso li bonts'itse hore liphetoho tse teng sebopehong sa phospholipid le metabolism li ka kenya letsoho ho theoheng ha kelello ho amanang le lilemo le mafu a neurodegenerative joalo ka lefu la Alzheimer's. Ho feta moo, tlatsetso ea phospholipid, haholo-holo e tsepamisitseng maikutlo ho phosphatidylserine, e bonts'itse ts'episo ea ho ts'ehetsa botsofali bo botle ba boko le ho fokotsa ho fokotseha ha kelello ho amanang le botsofali. Liphuputso tsena li totobatsa bohlokoa ba phospholipids moelelong oa botsofali ba boko le bokooa ba kelello bo amanang le lilemo.

VII. Liphello tsa Meriana le Litaelo tsa Bokamoso

A. Lisebelisoa tse ka bang teng bakeng sa bophelo bo botle ba boko le ts'ebetso ea kelello
Tšusumetso ea phospholipids ho bophelo bo botle ba boko le ts'ebetso ea kelello e na le litlamorao tse kholo bakeng sa ts'ebeliso e ka bang teng maemong a bongaka. Ho utloisisa karolo ea phospholipids ho ts'ehetsa bophelo bo botle ba boko ho bula monyetla oa ho kenella lipakeng tsa kalafo le maano a thibelo a reretsoeng ho ntlafatsa ts'ebetso ea kelello le ho fokotsa ho fokotseha ha kelello. Likopo tse ka 'nang tsa e-ba teng li kenyelletsa nts'etsopele ea mekhoa ea phekolo ea phospholipid, mekhoa ea tlatsetso e lokiselitsoeng, le mekhoa ea phekolo e lebisitsoeng ho batho ba kotsing ea ho senyeha ha kelello. Ntle le moo, ts'ebeliso e ka bang teng ea mehato e thehiloeng ho phospholipid ho ts'ehetsa bophelo bo botle ba boko le ts'ebetso ea kelello maemong a fapaneng a likliniki, ho kenyeletsoa batho ba tsofetseng, batho ba nang le mafu a neurodegenerative, le ba nang le bofokoli ba kelello, ba ts'episitse ho ntlafatsa sephetho se akaretsang sa kelello.

B. Menahano ea lipatlisiso tse tsoelang pele le liteko tsa bongaka
Liphuputso tse ling le liteko tsa bongaka li bohlokoa ho ntšetsa pele kutloisiso ea rona ea phello ea phospholipids ho bophelo bo botle ba boko le ts'ebetso ea kelello le ho fetolela tsebo e teng hore e be mekhoa e sebetsang ea bongaka. Lithuto tsa nako e tlang li lokela ho ikemisetsa ho hlakisa mekhoa e bakang litlamorao tsa phospholipids ho bophelo bo botle ba boko, ho kenyeletsoa tšebelisano ea bona le litsamaiso tsa methapo ea kutlo, litsela tsa lipontšo tsa cellular, le mekhoa ea neural plasticity. Ho feta moo, liteko tsa kliniki tsa longitudinal lia hlokahala ho lekola litlamorao tsa nako e telele tsa phospholipid ts'ebetsong ea kelello, botsofali ba boko, le kotsi ea maemo a neurodegenerative. Menahano ea lipatlisiso tse tsoelang pele e boetse e kenyelletsa ho hlahloba litlamorao tse ka bang teng tsa phospholipids le metsoako e meng ea bioactive, joalo ka omega-3 fatty acids, ho nts'etsapele bophelo bo botle ba boko le ts'ebetso ea kelello. Ho feta moo, liteko tsa kliniki tse hlophisitsoeng tse shebaneng le palo e itseng ea bakuli, joalo ka batho ba maemong a fapaneng a ho holofala ha kelello, li ka fana ka leseli la bohlokoa mabapi le ts'ebeliso e hlophisitsoeng ea phospholipid.

C. Liphello bakeng sa bophelo bo botle ba sechaba le thuto
Litlamorao tsa phospholipids mabapi le bophelo bo botle ba boko le ts'ebetso ea kelello li atoloha ho bophelo bo botle ba sechaba le thuto, ka litlamorao tse ka bang teng mabapi le maano a thibelo, maano a bophelo bo botle ba sechaba, le maano a thuto. Phatlalatso ea tsebo mabapi le karolo ea phospholipids bophelong bo botle ba boko le ts'ebetso ea kelello e ka tsebisa matšolo a bophelo bo botle ba sechaba a reretsoeng ho khothaletsa mekhoa e metle ea ho ja e tšehetsang ho ja phospholipid e lekaneng. Ho feta moo, mananeo a thuto a shebaneng le batho ba fapaneng, ho kenyeletsoa batho ba baholo, bahlokomeli le litsebi tsa tlhokomelo ea bophelo bo botle, a ka hlokomelisa ka bohlokoa ba phospholipids ho boloka botsitso ba kelello le ho fokotsa kotsi ea ho fokotseha ha kelello. Ho feta moo, ho kopanngoa ha tlhahisoleseding e thehiloeng bopaking mabapi le phospholipids ho kharikhulamo ea thuto bakeng sa litsebi tsa bophelo bo botle, litsebi tsa phepo e nepahetseng, le barupeli ho ka ntlafatsa kutloisiso ea karolo ea phepo e nepahetseng bophelong bo botle ba kelello le ho matlafatsa batho ka bomong ho etsa liqeto tse nang le tsebo mabapi le boiketlo ba bona ba kelello.

VIII. Qetello

Nakong ea tlhahlobo ena eohle ea phello ea phospholipids ho bophelo bo botle ba boko le ts'ebetso ea kelello, lintlha tse 'maloa tsa bohlokoa li hlahile. Taba ea pele, li-phospholipids, joalo ka likarolo tsa bohlokoa tsa lera la lisele, li bapala karolo ea bohlokoa ho bolokeng bots'epehi ba sebopeho le ts'ebetso ea boko. Taba ea bobeli, phospholipids e kenya letsoho tšebetsong ea kelello ka ho ts'ehetsa neurotransmission, synaptic plasticity, le bophelo bo botle ba boko ka kakaretso. Ho feta moo, phospholipids, haholo-holo tse nang le mafura a mangata a polyunsaturated, li amahanngoa le liphello tsa neuroprotective le melemo e ka bang teng bakeng sa ts'ebetso ea kelello. Ho feta moo, lintlha tsa lijo le mokhoa oa bophelo tse susumetsang sebopeho sa phospholipid li ka ama bophelo bo botle ba boko le ts'ebetso ea kelello. Qetellong, ho utloisisa phello ea phospholipids ho bophelo bo botle ba boko ho bohlokoa bakeng sa ho nts'etsapele mehato e reretsoeng ho khothaletsa botsitso ba kelello le ho fokotsa kotsi ea ho fokotseha ha kelello.

Ho utloisisa phello ea phospholipids ho bophelo bo botle ba boko le ts'ebetso ea kelello ho bohlokoa haholo ka mabaka a 'maloa. Taba ea pele, kutloisiso e joalo e fana ka leseli mabapi le mekhoa ea ts'ebetso ea kelello, e fanang ka menyetla ea ho nts'etsapele mehato e reretsoeng ho ts'ehetsa bophelo bo botle ba boko le ho ntlafatsa ts'ebetso ea kelello bophelong bohle. Taba ea bobeli, ha lilemo tsa baahi ba lefats'e le ho ata ha ho fokotseha ho amanang le botsofali ho ntse ho eketseha, ho hlakisa karolo ea phospholipids botsofaling ba kelello ho ba bohlokoa haholo bakeng sa ho khothaletsa botsofali bo botle le ho boloka ts'ebetso ea kelello. Taba ea boraro, phetoho e ka bang teng ea sebopeho sa phospholipid ka mekhoa ea lijo le mokhoa oa bophelo e hatisa bohlokoa ba tlhokomeliso le thuto mabapi le mehloli le melemo ea phospholipid ho ts'ehetsa ts'ebetso ea kelello. Ho feta moo, ho utloisisa phello ea phospholipids ho bophelo bo botle ba boko ho bohlokoa bakeng sa ho tsebisa maano a bophelo bo botle ba sechaba, mehato ea bongaka, le mekhoa ea motho ka mong e reretsoeng ho khothaletsa botsitso ba kelello le ho fokotsa ho fokotseha ha kelello.

Qetellong, phello ea phospholipids ho bophelo bo botle ba boko le ts'ebetso ea kelello ke sebaka sa lipatlisiso se nang le likarolo tse ngata le tse matla tse nang le liphello tse kholo bakeng sa bophelo bo botle ba sechaba, boikoetliso ba meriana, le bophelo bo botle ba motho ka mong. Ha kutloisiso ea rona ea karolo ea phospholipids ts'ebetsong ea kelello e ntse e tsoela pele ho fetoha, ho bohlokoa ho lemoha bokhoni ba ho kenella ho lebisitsoeng le maano a motho ka mong a sebelisang melemo ea phospholipids bakeng sa ho khothaletsa botsitso ba kelello bophelong bohle. Ka ho kenyelletsa tsebo ena mererong ea bophelo bo botle ba sechaba, boikoetliso ba bongaka, le thuto, re ka matlafatsa batho ka bomong ho etsa liqeto tse nang le tsebo tse tšehetsang bophelo bo botle ba boko le ts'ebetso ea kelello. Qetellong, ho khothaletsa kutloisiso e felletseng ea phello ea phospholipids bophelong bo botle ba boko le ts'ebetso ea kelello ho na le ts'episo ea ho ntlafatsa sephetho sa kelello le ho khothaletsa botsofali bo botle.

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