Ha letlalo le ntse le hōla, ho na le ho fokotseha ha mosebetsi oa physiologic. Liphetoho tsena li hlahisoa ke mabaka a mabeli a kahare (chronologic) le a kantle (haholo-holo a susumetsoa ke UV). Botanicals e fana ka melemo e ka bang teng ho loants'a tse ling tsa matšoao a botsofali. Mona, re hlahloba li-botanicals tse khethiloeng le bopaki ba mahlale ba liqoso tsa bona tse khahlanong le botsofali. Botanicals e ka fana ka anti-inflammatory, antioxidant, moisturizing, UV-protection, le litlamorao tse ling. Bongata ba li-botanicals bo thathamisitsoe e le metsoako ea litlolo le litlolo tse tsebahalang, empa ke tse 'maloa feela tse khethiloeng mona. Tsena li khethiloe ho itšetlehile ka boteng ba boitsebiso ba saense, thahasello ea botho ea bangoli, le "botumo" bo nahanoang ba lihlahisoa tsa morao-rao tsa litlolo le litlolo. Li-botanical tse hlahlobiloeng mona li kenyelletsa oli ea argan, oli ea kokonate, crocin, feverfew, tee e tala, marigold, kharenate le soya.
Mantsoe a bohlokoa: botanical; anti-botsofali; oli ea argan; oli ea kokonate; crocin; feberu; tee e tala; marigold; kharenate; soya
3.1. Oli ea Argan
3.1.1. Histori, Tšebeliso le Likopo
Oli ea Argan e tloaelehile Morocco 'me e hlahisoa ho tloha peo ea Argania sponosa L. E na le lisebelisoa tse ngata tsa setso tse kang ho pheha, ho phekola mafu a letlalo, le tlhokomelo ea letlalo le moriri.
3.1.2. Sebopeho le Mokhoa oa Ts'ebetso
Oli ea Argan e entsoe ka 80% ea mafura a monounsaturated le 20% ea mafura a mafura a mafura 'me e na le polyphenols, tocopherols, sterols, squalene, le joala ba triterpene.
3.1.3. Bopaki ba Saense
Ka tloaelo oli ea Argan e ne e sebelisoa Morocco ho fokotsa mebala ea sefahleho, empa motheo oa saense oa tseko ena o ne o sa utloisisoe pele. Phuputsong ea mouse, oli ea argan e ile ea thibela polelo ea tyrosinase le dopachrome tautomerase liseleng tsa B16 murine melanoma, e leng se bakang ho fokotseha ho itšetlehileng ka tekanyo ea melanin. Sena se fana ka maikutlo a hore oli ea argan e ka 'na ea e-ba inhibitor e matla ea melanin biosynthesis, empa liteko tsa ho laola ka mokhoa o sa tloaelehang (RTC) litabeng tsa batho lia hlokahala ho netefatsa khopolo ena.
RTC e nyane ea basali ba 60 ba kamora ho ilela khoeli ba khothalelitse hore tšebeliso ea letsatsi le letsatsi le/kapa tšebeliso ea oli ea argan e fokotse tahlehelo ea metsi a transepidermal (TEWL), ho ntlafala ha letlalo, ho ipapisitse le keketseho ea R2 (ho sisinyeha ho hoholo ha letlalo), R5. (letlapa la elasticity ea letlalo), le litekanyetso tsa R7 (biological elasticity) le ho fokotseha ha nako ea ho sebetsa ha resonance (RRT) (tekanyo e fapaneng e amanang le elasticity ea letlalo). Lihlopha li ne li khethiloe hore li je oli ea mohloaare kapa oli ea argan. Lihlopha tsena ka bobeli li ile tsa sebelisa oli ea argan letsohong le letšehali feela. Litekanyo li ne li nkoa ho tloha ka letsoho le letona le le letšehali la volar. Lintlafatso tsa elasticity li ile tsa bonoa lihlopheng ka bobeli letsohong la letsoho moo oli ea argan e neng e sebelisoa ka holimo, empa letsohong moo oli ea argan e sa kang ea sebelisoa feela sehlopha se jang oli ea argan se bile le keketseho e kholo ea elasticity [31]. Sena se ne se bakoa ke ho eketseha ha li-antioxidant ka har'a oli ea argan ha ho bapisoa le oli ea mohloaare. Ho nahanoa hore sena se ka bakoa ke vithamine E ea eona le li-ferulic acid, tse tsejoang e le li-antioxidants.
3.2. Kokonate Oli
3.2.1. Histori, Tšebeliso le Likopo
Oli ea kokonate e tsoa tholoaneng e omisitsoeng ea Cocos nucifera 'me e na le litšebeliso tse ngata, tsa histori le tsa kajeno. E 'nile ea sebelisoa e le monko o monate, letlalo le ho lokisa moriri, le lihlahisoa tse ngata tsa litlolo. Le hoja oli ea kokonate e na le lihlahisoa tse ngata, ho akarelletsa le kokonate acid, hydrogenated kokonate acid, le oli ea kokonate ea hydrogenated, re tla tšohla litlaleho tsa lipatlisiso tse amanang haholo le oli ea kokonate ea virgin (VCO), e lokiselitsoeng ntle le mocheso.
Oli ea kokonate e 'nile ea sebelisoa bakeng sa ho nosetsa letlalo la lesea 'me e ka ba molemo ho phekola atopic dermatitis bakeng sa thepa ea eona e mongobo le liphello tsa eona tse ka bang teng ho Staphylococcus aureus le likokoana-hloko tse ling tsa letlalo ho bakuli ba atopic. Oli ea kokonate e bontšitsoe ho fokotsa S. aureus colonization letlalong la batho ba baholo ba nang le atopic dermatitis ka RTC e foufetseng habeli.
3.2.2. Sebopeho le Mokhoa oa Ts'ebetso
Oli ea kokonate e entsoe ka 90-95% saturated triglycerides (lauric acid, myristic acid, caprylic acid, capric acid, le palmitic acid). Sena se fapane le lioli tse ngata tsa meroho/litholoana, tseo boholo ba tsona li entsoeng ka mafura a sa tsitsang. Li-triglycerides tse matlafalitsoeng tse sebelisoang ka holimo li sebetsa ho kolobisa letlalo joalo ka emollient ka ho batalatsa likarolo tse kobehileng tsa corneocyte le ho tlatsa likheo lipakeng tsa tsona.
3.2.3. Bopaki ba Saense
Oli ea kokonate e ka nosetsa letlalo le omileng la botsofali. Liperesente tse mashome a tšeletseng a metso e 'meli tsa mafura a acid a VCO a bolelele bo lekanang mme 92% e tletse, e lumellang ho paka ka thata ho fellang ka phello e kholo ea occlusive ho feta oli ea mohloaare. Li-triglycerides ka oli ea kokonate li robeha ke lipase limela tse tloaelehileng tsa letlalo ho ea ho glycerin le mafura a acid. Glycerin ke humectant e matla, e hohelang metsi karolong ea corneal ea epidermis ho tloha tikolohong e ka ntle le likarolo tse tebileng tsa letlalo. Mafura a mafura a VCO a na le linoleic acid e tlase, e bohlokoa kaha asiti ea linoleic e ka halefisa letlalo. Oli ea kokonate e phahametse oli ea diminerale ka ho fokotsa TEWL ho bakuli ba nang le atopic dermatitis 'me e sebetsa hantle ebile e sireletsehile joaloka oli ea diminerale ho phekola xerosis.
Lauric acid, e leng selelekela sa monolaurin le karolo ea bohlokoa ea VCO, e ka 'na ea e-ba le thepa e khahlanong le ho ruruha, e khona ho laola ho ata ha lisele tsa' mele tsa 'mele le ho ikarabella bakeng sa liphello tse ling tsa antimicrobial tsa VCO. VCO e na le maemo a phahameng a ferulic acid le p-coumaric acid (ka bobeli phenolic acid), 'me maemo a phahameng a li-phenolic acid tsena a amahanngoa le ho eketseha ha matla a antioxidant. Li-Phenolic acid li sebetsa khahlanong le tšenyo e bakoang ke UV. Leha ho le joalo, ho sa tsotellehe lipolelo tsa hore oli ea kokonate e ka sebetsa e le setlolo se sireletsang letsatsi, liphuputso tsa in vitro li fana ka maikutlo a hore e fana ka menyetla e fokolang ea ho thibela UV.
Ntle le litlamorao tsa eona tse mongobo le li-antioxidant, mehlala ea liphoofolo e fana ka maikutlo a hore VCO e ka fokotsa nako ea ho folisa maqeba. Ho ne ho e-na le boemo bo eketsehileng ba pepsin-soluble collagen (e phahameng collagen cross-linking) maqeba a phekoloang ke VCO ha a bapisoa le ho laola. Histopathology e bontšitse ho ata ha fibroblast e eketsehileng le neovascularization maqebeng ana. Lithuto tse ling lia hlokahala ho bona hore na ts'ebeliso ea litaba ea VCO e ka eketsa maemo a collagen letlalong la motho le tsofetseng.
3.3. Crocin
3.3.1. Histori, Tšebeliso, Litlaleho
Crocin ke karolo ea biologically e sebetsang ea safrone, e nkiloeng ho sekhobo se omisitsoeng sa Crocus sativus L. Safrone e lengoa linaheng tse ngata tse kenyeletsang Iran, India le Greece, 'me e sebelisitsoe meriana ea setso ho fokotsa maloetse a sa tšoaneng a akarelletsang ho tepella maikutlong, ho ruruha. , lefu la sebete, le tse ling tse ngata.
3.3.2. Sebopeho le Mokhoa oa Ts'ebetso
Crocin e ikarabella bakeng sa 'mala oa safrone. Crocin e boetse e fumanoa litholoana tsa Gardenia jasminoides Ellis. E khetholloa e le carotenoid glycoside.
3.3.3. Bopaki ba Saense
Crocin e na le litlamorao tsa antioxidant, e sireletsa squalene khahlano le peroxidation e bakoang ke UV, hape e thibela ho lokolloa ha bakena-lipakeng ba ho ruruha. Phello ea antioxidant e bontšitsoe ka in vitro assays e bontšitseng ts'ebetso e phahameng ea antioxidant ha e bapisoa le Vitamin C. Ho phaella moo, crocin e thibela UVA-induced cell membrane peroxidation 'me e thibela polelo ea bahlaseli ba bangata ba pro-inflammatory ho akarelletsa le IL-8, PGE-2, IL. -6, TNF-α, IL-1α, le LTB4. E boetse e fokotsa polelo ea mefuta e mengata e itšetlehileng ka NF-κB. Phuputsong e sebelisang li-fibroblasts tsa batho, crocin e fokotsitse ROS e hlahisoang ke UV, e khothalelitse polelo ea protheine ea extracellular matrix Col-1, le ho fokotsa palo ea lisele tse nang le li-phenotypes tsa senescent ka mor'a mahlaseli a UV. E fokotsa tlhahiso ea ROS mme e fokotsa apoptosis. Crocin e bontšitsoe ho hatella litsela tsa lipontšo tsa ERK/MAPK/NF-κB/STAT liseleng tsa HaCaT in vitro. Le hoja crocin e na le bokhoni ba ho ba cosmeceutical e thibelang botsofali, motsoako o na le labile. Tšebeliso ea li-nanostructured lipid dispersions bakeng sa tsamaiso ea lihlooho e 'nile ea etsoa lipatlisiso ka liphello tse tšepisang. Ho fumana litlamorao tsa crocin in vivo, mehlala e meng ea liphoofolo le liteko tsa bongaka tse sa reroang lia hlokahala.
3.4. Feberu
3.4.1. Histori, Tšebeliso, Litlaleho
Feverfew, Tanacetum parthenium, ke setlama se sa feleng se 'nileng sa sebelisetsoa merero e mengata meriana ea setso.
3.4.2. Sebopeho le Mokhoa oa Ts'ebetso
Feverfew e na le parthenolide, sesquiterpene lactone, e ka 'nang ea ikarabella bakeng sa tse ling tsa liphello tsa eona tse khahlanong le ho ruruha, ka ho thibela NF-κB. Thibelo ena ea NF-κB e bonahala e ikemetse ho liphello tsa antioxidant tsa parthenolide. Parthenolide e boetse e bonts'itse litlamorao tsa anticancer khahlano le mofets'e oa letlalo o bakoang ke UVB le khahlano le lisele tsa melanoma in vitro. Ka bomalimabe, parthenolide e ka boela ea baka ho hanana le maikutlo, makhopho a molomo, le allergic contact dermatitis. Ka lebaka la matšoenyeho ana, hangata e tlosoa pele feberu e kenngoa lihlahisoa tsa litlolo.
3.4.3. Bopaki ba Saense
Ka lebaka la mathata a ka bang teng mabapi le tšebeliso ea li-parthenolide, lihlahisoa tse ling tsa morao-rao tsa litlolo tse nang le feverfew li sebelisa parthenolide-depleted feverfew (PD-feverfew), e ipolelang hore ha e na matla a ho susumetsa maikutlo. PD-feverfew e ka ntlafatsa ts'ebetso ea ho lokisa DNA letlalong, e leng monyetla oa ho fokotsa tšenyo ea DNA e bakoang ke UV. Phuputsong ea in vitro, PD-feverfew e ile ea fokotsa sebopeho sa hydrogen peroxide e entsoeng ke UV le ho fokotsa ho lokolloa ha cytokine ea pro-inflammatory. E bonts'itse litlamorao tse matla tsa antioxidant ho feta papiso, Vithamine C, le ho fokotsa erythema e bakoang ke UV ho RTC ea lithuto tse 12.
3.5. Green Tea
3.5.1. Histori, Tšebeliso, Litlaleho
Tee e tala e 'nile ea sebelisoa bakeng sa melemo ea eona ea bophelo bo botle Chaena ka lilemo tse makholo. Ka lebaka la litlamorao tsa eona tse matla tsa antioxidant, ho na le thahasello ho nts'etsopele ea mokhoa o tsitsitseng, oa bioavailable topical formulation.
3.5.2. Sebopeho le Mokhoa oa Ts'ebetso
Tee e tala, e tsoang ho Camellia sinensis, e na le metsoako e mengata ea bioactive e nang le liphello tse ka 'nang tsa e-ba khahlanong le botsofali, ho akarelletsa le caffeine, divithamini le polyphenols. Li-polyphenols tse ka sehloohong tsa tee e tala ke li-catechin, haholo-holo gallocatechin, epigallocatechin (ECG), le epigallocatechin-3-gallate (EGCG). Epigallocatechin-3-gallate e na le antioxidant, photoprotective, immunomodulatory, anti-angiogenic, le anti-inflammatory properties. Tee e tala e boetse e na le flavonol glycoside kaempferol e ngata, e monyang hantle letlalong ka mor'a ho sebelisoa ka holimo.
3.5.3. Bopaki ba Saense
Sehlahisoa sa tee e tala se fokotsa tlhahiso ea ROS ka har'a in vitro mme se fokolitse necrosis e bakoang ke ROS. Epigallocatechin-3-gallate (tea e tala polyphenol) e thibela ho lokolloa ha hydrogen peroxide ka UV, e hatella phosphorylation ea MAPK, 'me e fokotsa ho ruruha ka ts'ebetso ea NF-κB. Ho sebelisa letlalo la ex vivo ho tsoa ho mosali ea lilemo li 31 ea phetseng hantle, letlalo le entsoeng ka tee e tšoeu kapa e tala le ntšitsoeng le bonts'itse ho bolokoa ha lisele tsa Langerhans (lisele tse hlahisang antigen tse ikarabellang bakeng sa ho kenella ha 'mele letlalong) kamora ho pepesetsoa khanya ea UV.
Moetsong oa toeba, ts'ebeliso ea mantlha ea tee e tala pele e pepesehela UV e ile ea fokotsa erythema, ho fokotseha ha letlalo la leukocyte, le ho fokotsa ts'ebetso ea myeloperoxidase. E ka boela ea thibela 5-α-reductase.
Liphuputso tse 'maloa tse amang bafo ba batho li hlahlobile melemo e ka bang teng ea tšebeliso ea lihlooho tsa tee e tala. Tšebeliso e ka sehloohong ea emulsion ea tee e tala e ile ea thibela 5-α-reductase 'me ea lebisa ho fokotseha ha boholo ba microcomedone ho microcomedonal acne. Phuputsong e nyenyane ea libeke tse tšeletseng ea ho arohana ha sefahleho sa motho, tranelate e nang le EGCG e fokotsehile hypoxia-inducible factor 1 α (HIF-1α) le vascular endothelial growth factor (VEGF), e bontšang bokhoni ba ho thibela telangiectasias. Phuputsong e sa boneng habeli, tee e tala, tee e tšoeu, kapa koloi e ile ea sebelisoa feela marakong a baithaopi ba 10 ba phetseng hantle. Joale letlalo le ne le khantšitsoe ka 2 × minimal erythema dose (MED) ea UVR e entsoeng ke letsatsi. Litlhahlobo tsa letlalo tse tsoang liwebsaeteng tsena li bontšitse hore tšebeliso ea tee e tala kapa e tšoeu e ka fokotsa ho fokotseha ha lisele tsa Langerhans, ho ipapisitse le CD1a positivity. Ho ne ho boetse ho e-na le thibelo e sa fellang ea tšenyo ea DNA ea UV-induced oxidative, joalokaha ho pakoa ke ho fokotseha ha maemo a 8-OHdG. Phuputsong e fapaneng, baithaopi ba baholo ba 90 ba ile ba aroloa ka lihlopha tse tharo: Ha ho phekolo, tee e tala ea lihlooho, kapa tee e tšoeu ea lihlooho. Sehlopha se seng le se seng se ile sa aroloa hape ka mekhahlelo e sa tšoaneng ea mahlaseli a UV. In vivo sun protection factor e fumanoe e batla e le SPF 1.
3.6. Marigold
3.6.1. Histori, Tšebeliso, Litlaleho
Marigold, Calendula officinalis, ke semela se thunyang se monko o monate se nang le menyetla ea kalafo. E 'nile ea sebelisoa meriana ea setso Europe le United States e le moriana oa lihlooho bakeng sa ho chesa, matetetso, maqeba le makhopho. Marigold o boetse o bontšitse liphello tsa anticancer mefuteng ea murine ea kankere ea letlalo e se nang melanoma.
3.6.2. Sebopeho le Mokhoa oa Ts'ebetso
Likarolo tse kholo tsa lik'hemik'hale tsa marigolds ke steroids, terpenoids, mahala le esterified triterpene alcohols, phenolic acid, flavonoids, le metsoako e meng. Le hoja phuputso e 'ngoe e bontšitse hore tšebeliso ea lihlooho tsa marigold e ka fokotsa ho teba le bohloko ba mahlaseli a kotsi ho bakuli ba fumanang mahlaseli bakeng sa mofetše oa matsoele, liteko tse ling tsa bongaka li bontšitse hore ha li phahame ha li bapisoa le ho sebelisoa ha aqueous cream feela.
3.6.3. Bopaki ba Saense
Marigold e na le matla a antioxidant le litlamorao tsa cytotoxic liseleng tsa mofetše oa motho ka mokhoa oa in vitro oa sele ea letlalo la motho. Phuputsong e fapaneng ea in vitro, tranelate e nang le oli ea calendula e ile ea hlahlojoa ka UV spectrophotometric 'me ea fumanoa e e-na le sekhahla sa ho monya ka har'a 290-320 nm; sena se ne se nkoa ho bolela hore ho sebelisoa ha tranelate ena ho fana ka tšireletso e ntle ea letsatsi. Leha ho le joalo, ke habohlokoa ho hlokomela hore sena e ne e se teko ea in vivo e neng e balla tekanyo e fokolang ea erythema ho baithaopi ba batho 'me ho ntse ho sa hlaka hore na sena se tla fetolela joang litekong tsa bongaka.
Ka mohlala oa in vivo murine, marigold extract e bontšitse phello e matla ea antioxidant ka mor'a ho pepeseha ha UV. Phuputsong e fapaneng, e amanang le likhoto tsa albino, tšebeliso ea lihlooho tsa oli ea calendula e ile ea fokotsa malondialdehyde (letšoao la khatello ea kelello ea oxidative) ha e ntse e eketsa maemo a catalase, glutathione, superoxide dismutase, le ascorbic acid letlalong.
Phuputsong e entsoeng ka libeke tse robeli e nang le batho ba 21, ho sebelisoa ha tranelate ea calendula marameng ho ile ha eketsa ho tiea ha letlalo, empa ha hoa ka ha e-ba le liphello tsa bohlokoa ho elasticity ea letlalo.
Moeli o ka bang teng oa tšebeliso ea marigold ka litlolo ke hore marigold ke sesosa se tsebahalang sa allergic contact dermatitis, joalo ka litho tse ling tse 'maloa tsa lelapa la Compositae.
3.7. Kharenate
3.7.1. Histori, Tšebeliso, Litlaleho
Kharenate, Punica granatum, e na le matla a antioxidant a matla 'me e sebelisitsoe lihlahisoa tse ngata e le topical antioxidant. Likahare tsa eona tse phahameng tsa antioxidant li etsa hore e be motsoako o khahlisang oa litlolo tsa litlolo.
3.7.2. Sebopeho le Mokhoa oa Ts'ebetso
Likarolo tse sebetsang tsa biologically tsa kharenate ke tannins, anthocyanins, ascorbic acid, niacin, potasiamo le alkaloids ea piperidine. Likaroloana tsena tse sebetsang ka bioloji li ka ntšoa lero, peo, lekhapetla, makhapetla, motso kapa kutu ea kharenate. Tse ling tsa likarolo tsena ho nahanoa hore li na le antitumor, anti-inflammatory, anti-microbial, antioxidant, le liphello tsa photoprotective. Ho feta moo, kharenate ke mohloli o matla oa polyphenols. Ellegic acid, e leng karolo ea motsoako oa kharenate, e ka fokotsa 'mala oa letlalo. Ka lebaka la ho ba motsoako o tšepisang oa ho thibela botsofali, liphuputso tse ngata li batlisisitse mekhoa ea ho eketsa ho kenella ha letlalo la motsoako ona bakeng sa tšebeliso ea lihlooho.
3.7.3. Bopaki ba Saense
Motsoako oa tholoana ea kharenate e sireletsa li-fibroblasts tsa motho, in vitro, ho tloha lefung la lisele tse bakoang ke UV; mohlomong ka lebaka la ho fokotseha ha ts'ebetso ea NF-κB, ho fokotseha ha proapoptotic caspace-3, le ho eketseha ha DNA tokiso. E bonts'a litlamorao tse khothalletsang anti-skin-tumor in vitro mme e thibela ho feto-fetoha ha UVB ho NF-κB le MAPK litsela. Tšebeliso ea lihlooho tsa makhapetla a kharenate e theola COX-2 letlalong le sa tsoa ntšoa la nama ea kolobe, e bakang litlamorao tse kholo tse khahlanong le ho ruruha. Le hoja ellegic acid e atisa ho nkoa e le karolo e sebetsang ka ho fetisisa ea kharenate ea kharenate, mohlala oa murine o bontšitse mosebetsi o phahameng oa ho thibela ho ruruha ka mokhoa o tloaelehileng oa kharenate ea rind ha e bapisoa le ellegic acid feela. Tšebeliso e ka sehloohong ea microemulsion ea pomegranate extract e sebelisa polysorbate surfactant (Tween 80®) papisong ea sefahleho se arohaneng ea libeke tse 12 le batho ba 11, e bontšitse melanin e fokotsehileng (ka lebaka la tyrosinase inhibition) le ho fokotseha ha erythema ha e bapisoa le taolo ea koloi.
3.8. Soya
3.8.1. Histori, Tšebeliso, Litlaleho
Li-soya ke lijo tse nang le protheine e ngata tse nang le likaroloana tsa bioactive tse ka bang le liphello tse thibelang botsofali. Haholo-holo, linaoa tsa soya li na le li-isoflavone tse ngata, tse ka 'nang tsa e-ba le liphello tsa anticarcinogenic le liphello tse kang tsa estrogen ka lebaka la sebopeho sa diphenolic. Litlamorao tsena tse kang estrogen li ka khona ho loants'a tse ling tsa litlamorao tsa ho khaotsa ho ilela khoeli botsofaling ba letlalo.
3.8.2. Sebopeho le Mokhoa oa Ts'ebetso
Soy, e tsoang ho Glycine maxi, e na le protheine e ngata 'me e na le li-isoflavone, tse kenyeletsang glycitein, equol, daidzein, le genistein. Li-isoflavone tsena, tseo hape li bitsoang phytoestrogens, li ka ba le litlamorao tsa estrogenic ho batho.
3.8.3. Bopaki ba Saense
Li-soya li na le li-isoflavone tse ngata tse nang le melemo ea ho thibela botsofali. Har'a litlamorao tse ling tsa biologic, glycitein e bonts'a litlamorao tsa antioxidant. Dermal fibroblasts e tšoaroang ka glycitein e bontšitse ho eketseha ha lisele le ho falla, ho eketseha ha motsoako oa mofuta oa collagen I le III, le ho fokotseha ha MMP-1. Phuputsong e arohaneng, soy extract e kopantsoe le haematococcus extract (algae ea metsi a hloekileng le eona e phahame ka li-antioxidants), e ileng ea theola MMP-1 mRNA le polelo ea protheine. Daidzein, soy isoflavone, e bontšitse litlamorao tse khahlanong le wrinkles, ho khantša letlalo, le litlamorao tsa ho nosetsa letlalo. Diadzein e ka sebetsa ka ho kenya tšebetsong estrogen-receptor-β letlalong, e leng se hlahisang polelo e ntlafetseng ea li-antioxidants tse sa feleng le ho fokotseha ha polelo ea lintlha tse ngotsoeng tse lebisang ho ata ha keratinocyte le ho falla. Soy-derived isoflavonoid equol e ile ea eketsa collagen le elastin le ho fokotsa MMPs setso sa lisele.
Liphuputso tse ling tsa vivo murine li bonts'a ho fokotseha ha lefu la lisele tse bakoang ke UVB le ho fokotseha ha botenya ba epidermal liseleng ka mor'a tšebeliso ea lihlooho tsa li-isoflavone. Phuputsong ea liteko ho basali ba 30 ba postmenopausal, tsamaiso ea molomo ea isoflavone extract bakeng sa likhoeli tse tšeletseng e hlahisitse botenya bo eketsehileng ba letlalo le ho eketseha ha collagen ea letlalo joalokaha ho lekantsoe ka li-biopsies tsa letlalo libakeng tse sirelelitsoeng ke letsatsi. Phuputsong e 'ngoe, li-isoflavone tsa soya tse hloekisitsoeng li thibetse lefu la keratinocyte le bakoang ke UV le ho fokotsa TEWL, botenya ba epidermal le erythema letlalong la mouse le pepesitsoeng ke UV.
RCT e nang le bokooa bo habeli ea basali ba 30 ba lilemo li 45-55 e ile ea bapisa tšebeliso ea lihlooho tsa estrogen le genistein (soy isoflavone) letlalong bakeng sa libeke tsa 24. Le hoja sehlopha se sebelisang estrogen letlalong se bile le liphello tse phahameng, lihlopha tsena ka bobeli li bontšitse ho eketseha ha mofuta oa I le oa III oa sefahleho sa collagen e thehiloeng ho li-biopsies tsa letlalo la letlalo la pele ho nako. Soy oligopeptides e ka fokotsa index ea erythema letlalong le pepesehileng UVB (forearm) le ho fokotsa lisele tsa ho chesoa ke letsatsi le dimers tsa cyclobutene pyrimidine liseleng tsa letlalo la setho sa setho sa UVB-radiated ex vivo. Teko ea tleliniki ea libeke tse 12 e laoloang ke koloi e sa boneng habeli e kenyelletsang basali ba 65 ba nang le foto ea sefahleho e itekanetseng e bonts'itse ntlafatso ea 'mala o mosoeu, botsoa, botsoa, mela e metle, sebopeho sa letlalo le letlalo ha li bapisoa le koloi. Ka kopanelo, lintlha tsena li ka fana ka litlamorao tse ka thibelang botsofali, empa liteko tsa kliniki tse sa fetoheng li hlokahala ho bonts'a molemo oa eona ka mokhoa o lekaneng.
4. Puisano
Lihlahisoa tsa botanical, ho kenyeletsoa le tseo ho buisanoeng ka tsona mona, li na le litlamorao tse ka thibelang botsofali. Mekhoa ea botanical e thibelang botsofali e kenyelletsa matla a mahala a ho lahla li-antioxidants tse sebelisoang ka holimo, ho eketsa tšireletso ea letsatsi, ho eketsa mongobo oa letlalo, le liphello tse ngata tse lebisang ho eketseha ha collagen kapa ho fokotseha ha collagen. Tse ling tsa liphello tsena li itekanetse ha li bapisoa le meriana, empa sena ha se theole melemo ea bona e ka 'nang ea e-ba teng ha e sebelisoa hammoho le mehato e meng e kang ho qoba letsatsi, tšebeliso ea li-sunscreens, moisturization ea letsatsi le letsatsi le phekolo e nepahetseng ea litsebi tsa bongaka tsa maemo a teng a letlalo.
Ho feta moo, litsebi tsa botanical li fana ka lisebelisoa tse ling tsa bioloji bakeng sa bakuli ba ratang ho sebelisa metsoako ea "tlhaho" feela letlalong la bona. Le hoja metsoako ena e fumanoa ka tlhaho, ke habohlokoa ho hatisa ho bakuli hore sena ha se bolele hore metsoako ena e na le liphello tse mpe, ha e le hantle, lihlahisoa tse ngata tsa botanical li tsejoa e le sesosa se ka 'nang sa baka allergic contact dermatitis.
Kaha lihlahisoa tsa litlolo ha li hloke tekanyo e lekanang ea bopaki ho paka hore li sebetsa hantle, hangata ho thata ho fumana hore na lipolelo tsa liphello tse khahlanong le botsofali ke 'nete. Leha ho le joalo, tse 'maloa tsa botanical tse thathamisitsoeng mona li na le litlamorao tse ka thibelang botsofali, empa ho hlokahala liteko tse matla tsa bongaka. Le hoja ho le thata ho bolela esale pele hore na mahlahana ana a botanical a tla tsoela bakuli le bareki molemo ka ho toba nakong e tlang, ho ka etsahala hore boholo ba li-botanicals tsena, lihlahisoa tse li kenyelletsang e le metsoako li tla tsoela pele ho hlahisoa e le lihlahisoa tsa tlhokomelo ea letlalo le haeba li ho boloka moeli o pharaletseng oa polokeho, kamohelo e phahameng ea bareki, le theko e nepahetseng, li tla lula e le karolo ea mekhoa e tloaelehileng ea tlhokomelo ea letlalo, e fanang ka melemo e fokolang ho bophelo bo botle ba letlalo. Bakeng sa palo e lekanyelitsoeng ea li-agent tsena tsa botanical, leha ho le joalo, tšusumetso e kholo ho baahi ka kakaretso e ka fumanoa ka ho matlafatsa bopaki ba liketso tsa bona tsa tlhaho, ka litlhahlobo tse phahameng tsa "biomarker" tse tloaelehileng 'me ka mor'a moo li beha lipakane tse tšepisang ka ho fetisisa tekong ea liteko tsa tleliniki.
Nako ea poso: May-11-2023
